Germacranolide / PD-1 Cancer Research Results

Ger, Germacranolide: Click to Expand ⟱

Features:

A germacranolide sesquiterpene lactone (GSL) was isolated from Siegesbeckia glabrescens

PD-1, Programmed Death-1: Click to Expand ⟱

Source:

Type: protein

PD-1 (Programmed Death-1) is a protein that plays a crucial role in the immune system's ability to fight cancer. It is a checkpoint protein that helps regulate the immune response by preventing the immune system from attacking healthy cells.
PD-1 is often exploited by cancer cells to evade the immune system. Cancer cells can produce proteins that bind to PD-1, inhibiting the immune response and allowing the cancer cells to grow and proliferate unchecked.

However, researchers have discovered that blocking the PD-1 pathway can help restore the immune system's ability to fight cancer. This has led to the development of PD-1 inhibitors, a class of cancer therapies that target the PD-1 protein.

PD-1: Upregulated on tumor-infiltrating lymphocytes (TILs), reflecting chronic antigen exposure and an “exhausted” T cell phenotype.
PD-L1 and PD-L2: Frequently overexpressed by many tumor types (e.g., non–small cell lung cancer, melanoma, renal cell carcinoma, head and neck cancers).

Scientific Papers found: Click to Expand⟱

1048-

RosA,

Ger,

Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis

in-vivo,

Colon,

MC38

RA (50, 100, 150 μM)

mice

TumCMig↓, TumCI↓, PD-1↓, COX2↓, PD-L1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Migration ⓘ

TumCI↓, 1, TumCMig↓, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 1, PD-1↓, 1, PD-L1↓, 1,

Clinical Biomarkers ⓘ

PD-L1↓, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: PD-1, Programmed Death-1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells