CYP2E1 Cancer Research Results

CYP2E1, cytochrome P450 2E1 (CYP2E1): Click to Expand ⟱
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CYP2E1 is an enzyme belonging to the cytochrome P450 family that is primarily involved in the metabolism of small organic molecules, including drugs, toxins, and endogenous substrates. It plays a significant role in the biotransformation of various compounds through oxidation reactions.

Due to its role in metabolizing procarcinogenic compounds, elevated CYP2E1 activity has been linked to an increased risk of certain cancers, particularly in the context of chronic alcohol consumption or exposure to environmental toxins. In some studies, higher CYP2E1 levels have been associated with liver cancer and may also influence risk in other tissues.
Scientific Papers found: Click to Expand⟱
7769- IBC,    Potential Determinants for Metabolic Fates and Inhibitory Effects of Isobavachalcone Involving in Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Efflux Transporters
- in-vivo, NA, NA
*AntiCan↑, Isobavachalcone, a naturally occurring chalcone in Psoralea corylifolia, posses many biological properties including anticancer, antiplatelet, and antifungal.
*AntiAg↑,
*AntiFungal↑,
CYP2C9↓, isobavachalcone demonstrated broad-spectrum inhibitory effects against CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, UGT1A1, UGT1A9, UGT2B7 with IC50 values of 1.08-9.78 μM.
UGT1A↓,
CYP2D6↓,
CYP2E1↓,

8086- KAE,    Hepatoprotective Effect of Kaempferol: A Review of the Dietary Sources, Bioavailability, Mechanisms of Action, and Safety
- Review, Nor, NA
*hepatoP↑, Kaempferol is a potent antioxidant and has anti-inflammatory effects, which therefore possesses hepatoprotective properties.
*BioAv↝, 100 nM of kaempferol-3-glucuronide (79%) and 3-glucoside (14%) and 3-(6-malonyl)-glucoside (7%) were observed 5.8 hours after oral administration of endive containing 8.65 mg of kaempferol
*CYP2E1↓, Hepatoprotective effects of kaempferol on alcohol-induced liver damage in rats can be achieved via lowering CYP2E1 expression and increasing the antioxidant defense system's protective role
*antiOx↑,
*AST↓, Inhibition of OATP1B1 transporter and maintaining a level of AST and ALT
*ALAT↓,
*ROS↓, Reduced AA + Fe-induced ROS production. By giving up a hydrogen atom, it neutralizes free radicals and produces phenoxyl radicals.
*lipid-P↓, decreased oxidative stress and lipid peroxidation
*SIRT1↑, Kaempferol Suppresses Liver Damage by the Upregulation and Activation of SIRT1
*GSH↑, The compound can also induce reactive antioxidant enzymes (GSH and SOD)
*SOD↑,
*p‑SMAD2↓, Kaempferol Downregulates the Phosphorylation of Smad2 and Smad3
*p‑SMAD3↓,
*COL1↓, Kaempferol can inhibit the expression of type I collagen in HSCs and diminish the collagen density in the liver tissue.
*other↝, In contrast, the phenoxyl radical works as a pro-oxidant when it combines with oxygen species, reducing copper and iron ions that are crucial to lipid peroxidation and the generation of hydroxyl radicals

8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3-kinase (PI3K)/AKT
tumCV↓,
TumCCA↑,
PI3K↓,
Akt↓,
EMT↓, suppresses protein expression of epithelial-mesenchymal transition (EMT)-related markers including N-cadherin, E-cadherin, Slug, and Snail, and metastasis-related markers such as matrix metallopeptidase 2 (MMP-2).
N-cadherin↓,
E-cadherin↓, nhibition of N‐cadherin, E‐cadherin, Slug, Snail, and MMP‐2, 9, and cathepsin B, D
Slug?,
Snail?,
MMP2↓,
MMP9↓,
CTSB↓,
CTSD↓,
Casp3↑, Activation of caspase signals such as caspase‐3, ‐8, and ‐9
Casp8↑,
Casp9↑,
TIMP2↓, Down‐regulation of phosphorylated TIMP2, AKT, and MMP2 levels
Akt↓,
TumCD↑, Induction of cell apoptotic cell death, intracellular free calcium elevation, and mitochondrial membrane potential disruption.
i-Ca+2↑,
MMP↓,
*ROS↓, Enhances the concentrations of superoxide dismutase, catalase, glutathione peroxidase, and glutathione‐S‐transferase.
*SOD↑,
*Catalase↑,
*GPx↑,
*GSTs↑,
*AST↓, Lowers aspartate aminotransferase, alanine aminotransferase, malondialdehyde (MDA).
*ALAT↓,
*MDA↓,
*CYP2E1↓, Decreases activity of hepatic microsomal enzyme cytochrome 2E1 (CYP2E1) expression
*NRF2↑, Increases mRNA and protein expression of Nrf2‐regulated genes
*AGEs↓, Suppresses advanced glycation end products (AGEs)‐ receptor.
*IL6↓, Reduces levels of IL‐6, TNF‐α, and NF‐κB.
*TNF-α↓,
*NF-kB↓,
*Casp3↓, Lowers expressions of Caspase‐3 and Bax,
*BAX↓,
*antiAll↑, Antiallergic Inhibits COX2‐mediated production of prostaglandin D2 and prostaglandin F2α.
*COX2/PTGS2↓,
*PGE2↓,
*RUNX2↑, Increases expression of the osteoblast‐activated factors RUNX‐2, BMP‐2, osterix, collagen I, and SQSTM1/p62
*BMP2↑,
*COL1↑,
*p62↑,
*FASN↓, Reduces expressions of lipin1, FASN, LPAATθ (lysophosphatidic acid acyltransferase), SREBP‐1C (fatty acid synthetic proteins), and DGAT1 (triglyceride synthetic enzymes).
*DGAT1↓,
FOXP3↑, kaempferol significantly enhanced the inhibitory effect of proliferation, increased the FOXP3 expression level,
DNAdam↑, s induction of DNA damage, enhancement DNA condensation
ROS↑, anti‐cancer property is mainly defined by ROS accumulation due to catalase inhibition as depicted in Figure 2
Catalase↓,
*ROS↓, (A/R)‐induced injury of cardiomyocytes by increasing cell viability, lowering LDH release, reducing A/R‐induced ROS generation, loss of Δψm, and release of cytochrome c from mitochondria into cytosol.
*MMP↑,
*Cyt‑c↓,

8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, Kaempferol, a naturally occurring flavonoid, has demonstrated significant hepatoprotective effects in preclinical models
*SIRT1↑, This substance activates the SIRT1/AMPK signalling pathway, improves mitochondrial function, inhibits proinflammatory cytokine production via TLR4/NF-κB suppression and attenuates hepatic stellate cell activation by modulating the TGF-β/Smad pathwa
*AMPK↑,
*TLR4↓,
*NF-kB↓,
*GutMicro↑, kaempferol regulates the composition of the gut microbiota, thus improving bile acid metabolism and alleviating steatosis and fibrosis.
*Dose↝, The most significant amounts of kaempferol can be found in vegetables such as kale, spinach, onions, or beverages, especially black or green tea infusions
*BioAv↓, the bioavailability of the various chemical forms of oral kaempferol is low and has been calculated to be around 2%
*BioAv↑, However, there are some modern approaches (nanoparticles, structural modifications, chimeric molecules) that could certainly be exploited to improve kaempferol bioavailability [
*CYP2E1↓, including SIRT1 activation, CYP2E1 inhibition, TLR4/NF-κB suppression and ALK5/Smad pathway interference
*lipidLev↓, Reduction of Hepatic Lipid Accumulation
*COX2/PTGS2↓, Kaempferol can also suppress the production and expression of COX-2, IL-1β, TNF-α, and IL-6 mRNA, which play key roles in inflammation
*IL1β↓,
*TNF-α↓,
*IL6↓,
*NO↓, reduces the levels of NO and PGE2 while lowering iNOS mRNA expression in cases of acute liver injury.
*PGE2↓,
*iNOS↓,
*SOD↑, increased SOD activity and decreased MDA levels in the liver were observed when compared with the haemorrhagic shock group.
*MDA↓,
*ROS↓, inhibit CYP2E1 at both the expression and activity levels, consequently leading to a reduction in ROS levels and liver damage.
*AST↓, The significant decrease in serum AST and ALT levels is due to this inhibitory effect.
*ALAT↓,
*GSH↑, The induction of reactive antioxidant enzymes (GSH and SOD) by this compound
*SOD↑,
*Cyt‑c↓, inhibiting hepatocyte apoptosis through the reduction of apoptosis-related proteins, including cytochrome c, Bax, Bcl-2, caspases:3, 8 and 9
*BAX↓,
*Casp3↓,
*Casp8↓,
*Casp9↓,
*COL1↓, Kaempferol has been shown to be capable of inhibiting type I collagen expression in HSCs and reducing collagen density in liver tissue
*p‑SMAD2↓, reducing the phosphorylation of Smad2 and Smad3 by the serine/threonine kinase, attenuating α-SMA production, and inhibiting TGF-β-stimulated HSCs
*p‑SMAD3↑,
*α-SMA↓,
*TGF-β↓,
*P450↝, Kaempferol interacts with cytochrome P450 enzymes, including CYP3A4, which is key to drug metabolism.
*P-gp/ABCB1↓, It has been demonstrated that kaempferol is capable of inhibiting P-gp, which may consequently result in an enhancement of the bioavailability of drugs that are P-gp substrates.
*BioEnh↑,

8217- LCA,    Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice
- Study, Nor, NA
*CYP1A1↓, LCA significantly inhibited the activities of CYP1A2, 2C19, 2C8, 2C9 and 3A4 and exhibited weak inhibitory effects on CYP2E1 and CYP2D6.
*CYP2C19↓,
*CYP2C8↓,
*CYP2C9↓,
*CYP3A4↓,
*CYP2E1↓,
*CYP2D6↓,
*BioEnh↑, rediction results from the in vivo HDI risk experiments indicated that the AUCs of the CYP2C substrates increased by 2–398% when these drugs were co-administrated with LCA.
eff↑, low-dose liquorice or LCA may slightly increase the AUCs of these CYP substrates, which could potentially increase their efficacies in the treatment of cancer.

4529- MAG,    Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities—A Review
- Review, Diabetic, NA
*AntiDiabetic↑,
*glucose↓, magnolol administered to rats with type 2 diabetes reduced fasting blood glucose and plasma insulin levels, without affecting their body weight
*SOD↑, increase in SOD and CAT activity
*Catalase↑,
*ROS↓, Magnolol acts as a free radical scavenger which was proven in numerous in vitro and in vivo studies
*MDA↓, decrease in MDA level
*GPx↑, increase in SOD, CAT and GPx activities, decrease in MDA level and CYP2E1 activity in the liver
*CYP2E1↓,
*AGEs↓, decrease in AGEs level in kidney glomeruli
*IL10↑, increase in IL-10 level in the plasma
*neuroP↑, numerous reports on the protective effect of magnolol on the nervous system, it can be assumed that this lignan may also have neuroprotective effects in the course of diabetes
*GutMicro↑, In the case of the intestinal microflora, honokiol had a beneficial effect on obtaining microbiota homeostasis increasing the amount of Akkermansia bacteria and reducing the amount of Oscillospira bacteria

5072- PEITC,    Inhibition and Inactivation of Human Cytochrome P450 Isoforms by Phenethyl Isothiocyanate
- in-vitro, Nor, NA
*CYP2E1↓, Furthermore, PEITC is a mechanism-based inactivator of human CYP2E1.
*chemoPv↑, The present study directly proved that the chemopreventive effects of PEITC for nitrosamine-induced carcinogenesis are due to the inhibition of CYP by an in vitro study.

6422- QC,    Quercetin Protects Ethanol-Induced Hepatocyte Pyroptosis via Scavenging Mitochondrial ROS and Promoting PGC-1α-Regulated Mitochondrial Homeostasis in L02 Cells
- in-vitro, Alcohol, L02
*mt-ROS↓, quercetin treatment downregulated redox status, lipid droplets, and LPO release, restored damaged mitochondrial membrane potential, and repaired mtDNA damage, PGC-1α nuclear transfer, and mitochondrial dynamics.
*lipid-P↓,
*MMP↑,
*mtDam↓,
*NLRP3↓, gene and protein expressions of NLRP3, ASC, cleaved-caspase1, IL-18, IL-1β, and GSDMD-N were decreased, which effectively inhibited cell pyroptosis.
*ASC↓,
*cl‑Casp1↓,
*IL18↓,
*IL1β↓,
*GSDMD↓,
*Pyro↓,
*CYP2E1↓, Quercetin Inhibited CYP2E1 Activity to Alleviate High-Concentration Ethanol-Induced Hepatocyte Oxidative Stress and Lipid Peroxidation
*MFN1↓, Our study found that quercetin inhibited the expressions of mitochondrial fusion genes including Mfn1, Mfn2, and OPA1,
*MFN2↓,
*OPA1↓,
*DRP1/DNM1L↑, as well as increased fission genes expressions, and and the most significant change was Drp1

1193- SM,    Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways
- in-vivo, Alcohol, NA - in-vitro, Liver, HepG2
*p‑AMPK↑,
*SIRT1↑,
*NRF2↑,
*CYP2E1↓,
*lipoGen↓,
*ROS↓,
*Inflam↓,


Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CYP2D6↓, 1,   UGT1A↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   CYP2E1↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CTSB↓, 1,   CTSD↓, 1,   EMT↓, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

i-Ca+2↑, 1,   E-cadherin↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Slug?, 1,   Snail?, 1,   TIMP2↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

FOXP3↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

CYP2C9↓, 1,   eff↑, 1,  
Total Targets: 30

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

antiAll↑, 1,   CYP2C19↓, 1,   CYP2C8↓, 1,   CYP2D6↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 2,   CYP1A1↓, 1,   CYP2E1↓, 8,   GPx↑, 2,   GSH↑, 2,   GSTs↑, 1,   lipid-P↓, 2,   MDA↓, 3,   MFN1↓, 1,   MFN2↓, 1,   NRF2↑, 2,   OPA1↓, 1,   ROS↓, 6,   mt-ROS↓, 1,   SOD↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↑, 1,   MMP↑, 2,   mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 1,   p‑AMPK↑, 1,   CYP3A4↓, 1,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,   lipidLev↓, 1,   lipoGen↓, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

BAX↓, 2,   BMP2↑, 1,   cl‑Casp1↓, 1,   Casp3↓, 2,   Casp8↓, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   GSDMD↓, 1,   iNOS↓, 1,   Pyro↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

RUNX2↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   COL1↓, 2,   COL1↑, 1,   p‑SMAD2↓, 2,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   COX2/PTGS2↓, 2,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 2,   IL6↓, 2,   Inflam↓, 1,   NF-kB↓, 2,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   BioEnh↑, 2,   CYP2C9↓, 1,   Dose↝, 1,   P450↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   AST↓, 3,   GutMicro↑, 2,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   chemoPv↑, 1,   hepatoP↑, 2,   neuroP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,  
Total Targets: 86

Scientific Paper Hit Count for: CYP2E1, cytochrome P450 2E1 (CYP2E1)
3 Kaempferol
1 Isobavachalcone
1 Licochalcone A
1 Magnolol
1 Phenethyl isothiocyanate
1 Quercetin
1 Salvia miltiorrhiza
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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