TLR1 Cancer Research Results

TLR1, Toll-Like Receptor 1: Click to Expand ⟱
Source:
Type:
TLR1 is one of the Toll-like receptors (TLRs), a family of pattern recognition receptors that play a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).

TLR1 expression is not confined solely to immune cells; its expression has also been detected in various tumor cells as well as in the surrounding stroma. Aberrant expression or activation of TLR1 in the tumor microenvironment can influence both innate and adaptive immune responses within tumors. This modulation can have complex effects on tumor progression.

Due to its dual role, TLR1 holds potential as both a prognostic biomarker and a therapeutic target.
Scientific Papers found: Click to Expand⟱
6315- Cro,    Functional Mechanisms of Dietary Crocin Protection in Cardiovascular Models under Oxidative Stress
- in-vivo, NA, NA
*cardioP↑, it protects cardiac cells and significantly inhibits inflammation via modulating molecular signaling pathways TLR4/PTEN/AKT/mTOR/NF-κB and microRNA (miR-21).
*Inflam↓,
*antiOx↑, crocin not only acts as a direct free radical scavenger but also modifies the gene expression profiles of HUVECs and protects mice hearts with anti-inflammatory action under oxidative stress. The results showed that the antioxidant activity of crocin
*ROS↓, inhibition of excessive ROS by carotenoids and antioxidant-based formulations are interesting approaches for better clinical efficacy and oxidative stress-derived damages.
*AntiCan↑, pharmacological properties of saffron as an antioxidant, anticancer, and memory-enhancing factor have been extensively studied in vitro and in vivo
*memory↑,
*NF-kB↓, downregulation of NF-κB/TLR signaling and an upregulation of Nrf-2 and HO-1 [16].
*TLR1↓,
*NRF2↑,
*HO-1↑,
*lipid-P↓, crocin could decrease lipid peroxidation during ischemia-reperfusion (I/R)-induced oxidative damage in the kidney
*DNAdam↓, Crocin Protection against HUVEC DNA Damage
PTEN↓, Down-regulation of PTEN was observed in crocin-treated cells.
MMP↓, Under oxidative stress, there is a significant loss of ΔΨm concurrent with cell death.

3432- TQ,    Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, It could be utilized to treat drug misuse or dependence, and those with memory and cognitive impairment
*cognitive↑,
*ROS↓, TQ protects brain cells from oxidative stress, which is especially pronounced in memory-related regions.
*Inflam↓, TQ’s antioxidant and anti-inflammatory properties protect brain cells from damage and inflammation.
*antiOx↑,
*TLR1↓, TQ’s role in inhibiting Toll-like receptors (TLRs) and some inflammatory mediators, leading to reduced inflammation and neurotoxicity.
*AChE↓, TQ has been shown in clinical studies to block acetylcholinesterase (AChE) activity, which increases acetylcholine (ACh).
*MMP↑, TQ ameliorates and prevents Aβ-induced neurotoxicity and mitochondrial membrane depolarization by inhibiting ROS formation and reducing oxidative stress by antioxidant properties.
*neuroP↑, TQ has an essential role in the neuroprotective impact on hippocampal cells after cerebral ischemia through the inhibition of lipid peroxidation
*lipid-P↓,
*SOD↑, This effect is due to the antioxidant activity of TQ on the levels of the superoxide dismutase (SOD) and GSH activities.
*GSH↑,
*Ach↑, TQ has been shown in clinical studies to block acetylcholinesterase (AChE) activity, which increases acetylcholine (ACh).


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

PTEN↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   GSH↑, 1,   HO-1↑, 1,   lipid-P↓, 2,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 2,   NF-kB↓, 1,   TLR1↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   cognitive↑, 1,   memory↑, 2,   neuroP↑, 1,  
Total Targets: 19

Scientific Paper Hit Count for: TLR1, Toll-Like Receptor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1041  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

Home Page