neuroP Cancer Research Results

neuroP, neuroprotective: Click to Expand ⟱
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Neuroprotective refers to the ability of a substance, intervention, or strategy to preserve the structure and function of nerve cells (neurons) against injury or degeneration.
-While cancer and neurodegenerative processes might seem distinct, there is significant overlap in terms of treatment-related neurotoxicity, shared molecular mechanisms, and the potential for therapies that provide neuroprotection during cancer treatment.
Scientific Papers found: Click to Expand⟱
5430- AG,    Review of the pharmacological effects of astragaloside IV and its autophagic mechanism in association with inflammation
- Review, Stroke, NA
*cardioP↑, Review of the pharmacological effects of astragaloside IV and its autophagic mechanism in association with inflammation - PMC
*MitoP↑, The mechanism included promotion of mitophagy, which reduced generation of mitochondrial ROS and accumulation of damaged mitochondria[31].
*ROS↓, AS-IV can reduce ROS-mediated autophagosome accumulation and myocardial injury caused by I/R[21]
*mtDam↓,
*neuroP↓, Ischemic stroke MCAO in SD rats; OGD/R in HT22 cells A neuroprotective role (-) apoptosis (+) autophagy
TumAuto↓, For NSCLC cells treated with cisplatin, AS-IV inhibited the increased autophagy of proteins Beclin1 and LC3 I/II
*AntiDiabetic↑, Protective effect of AS-IV on diabetes

4135- Alum,    Aluminum Should Now Be Considered a Primary Etiological Factor in Alzheimer's Disease
- Review, AD, NA
*Risk↑, The unequivocal neurotoxicity of aluminum must mean that when brain burdens of aluminum exceed toxic thresholds that it is inevitable that aluminum contributes toward disease.
*cognitive↓, EVIDENCE NOW POINTS TO ALUMINUM AS A CONTRIBUTORY FACTOR IN ALL FORMS OF ALZHEIMER’S DISEASE
*neuroP↓, We also know that the addition of aluminum to feed or water exacerbates the many symptoms of Alzheimer’s disease in these animal models
*other↑, Postmortem analyses of their brain tissues revealed very high levels of aluminum.
*other↝, physical exercise can increase the perspiration volume many times and so improve the excretion of aluminum from the body.

2790- CHr,    Chrysin: Pharmacological and therapeutic properties
- Review, Var, NA
*hepatoP↑, graphical abstract
*neuroP↓,
*ROS↓,
*cardioP↑,
*Inflam↓,
eff↑, suppression of hTERT and cyclin D1 gene expression in T47D breast cancer cell lines is due to the combined effect of metformin and chrysin
hTERT/TERT↓,
cycD1/CCND1↓,
MMP9↓, nanoparticle-based chrysin in C57B16 mice bearing B16F10 melanoma tumors was markedly presented reductions in the levels of MMP-9, MMP-2, and TERT genes, whereas it enhanced TIMP-2 andTIMP-1 genes expression
MMP2↓,
TIMP1↑,
TIMP2↑,
BioAv↑, nano-encapsulation of chrysin and curcumin improved the delivery of these phytochemicals that significantly inhibited the growth of cancer cells, while it decreased the hTERT gene expression via increased solubility and bioavailability
HK2↓, chrysin treatment restrained tumor growth in HCC xenograft models and significantly reduced HK-2 expression in tumor tissue
ROS↑, showing a significant increase in intracellular reactive oxygen species (ROS), cytotoxicity, mitochondrial membrane potential (MMP) collapse, caspase-3 activation, ADP/ATP ratio, and ultimately apoptosis
MMP↓,
Casp3↑,
ADP:ATP↑,
Apoptosis↑,
ER Stress↑, Likewise, chrysin encouraged endoplasmic reticulum (ER) stress via stimulation of unfolded protein response (UPR
UPR↑,
GRP78/BiP↝, (eIF2α), PRKR-like ER kinase (PERK) and 78 kDa glucose-regulated protein (GRP78).
eff↑, silibinin and chrysin synergistically inhibited growth of T47D BCC and downregulated the hTERT and cyclin D1 level
Ca+2↑, Primarily, increased ROS and cytoplasmic Ca 2+ levels alongside induction of cell death and loss of MMP are involved in inhibition of ovarian cancer through chrysin.

2519- H2,    Hydrogen: an advanced and safest gas option for cancer treatment
- Review, Var, NA
antiOx↑, H2 has remarkable antioxidant and neuroprotective effects and other advantages
neuroP↓,
BBB↑, swift penetration ability to cross the blood–brain barrier
toxicity∅, H2 inhalation therapy has also been proposed in several countries as the safest mode of H2 administration
TumCP↓, A HeLa xenograft mouse model showed that H2 inhalation may increase the apoptosis rate, proliferation, and oxidative stress in HeLa cells
Apoptosis↓,
ROS↑,
Hif1a↓, H2 may affect tumor growth by regulating the expression of overexpressed subunits of transcription factors, such as hypoxia-inducible factor 1α and the nuclear factor-κB p65 subunit
NF-kB↓,
P53?, Hydrogen also increases the expression level of p53 tumor suppressor proteins.
OS↑, This study revealed that hydrogen gas inhalation 3 h/d can improve the prognosis and overall survival of stage IV colorectal carcinoma patients by decreasing the number of programmed cell death 1/CD8+ T cells
chemoP↑, H 2 anticancer therapy can minimize the debilitating side effects of conventional anticancer therapies by improving survival, quality of life, and blood parameters.

7341- Hne,    Preclinical evaluation of safety and potential of black hellebore extracts for cancer treatment
- Review, Var, NA
angioG↓, HNE exerted anti-angiogenetic effects in HUVEC and anti-proliferative effects in five cancer cell lines
TumCP↓,
*Inflam↓, a broad pharmacological spectrum is ascribed to Christmas rose: anti-bacterial, anti-inflammatory, cholesterol- and blood glucose-lowering, neuroprotective, hepatoprotective and immune-modulating effects.
*Bacteria↓,
*glucose↓,
*neuroP↓,
*hepatoP↓,
*Imm↝,

8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, Kaempferol is a natural flavonoid with antioxidant, anti-inflammatory, neuroprotective, and anticancer effects.
*Inflam↓,
*neuroP↓,
*AntiCan↑,
DNAdam↓, kaempferol inhibited Nrf2 and induced ROS accumulation after 48 h of treatment, thereby making the NSCLC cells sensitive to apoptosis
Casp3↑,
Casp9↑,
p‑AMT/GCST/T-protein↑,
ROS↑, with ROS generation
NRF2↑, Kaempferol has been reported to activate Nrf2 and its downstream signaling pathways in multiple human cancer cell models, including MCF-7 breast cancer cells
Apoptosis↑, inducing apoptosis by increasing cleaved PARP and Bax and downregulating Bcl-2 expression, inducing cell cycle arrest at the G2/M phase;
cl‑PARP↓,
BAX↑,
Bcl-2↓,
TumCCA↓,
angioG↓, inhibiting the angiogenic and metastatic potential of tumors by downregulating MMP-3 and MMP-9 levels
MMP3↓,
MMP9↓,
ChemoSen↑, Kaempferol holds promise for boosting the efficacy of anticancer agents, complementing their effects, or reversing developed chemoresistance.
BioAv↓, Kaempferol has poor water solubility and has been studied extensively for its pharmacokinetic properties both in vitro and in vivo.
Glycolysis↓, They also demonstrated decreased aerobic glycolysis,
cl‑PARP↑, Their cell growth inhibition and apoptosis were linked to the activation of PARP cleavage
Ca+2↑, induction of apoptosis with a significant increase in cytoplasmic Ca2+ and decrease in mitochondria membrane potential (Δψm) levels in US-2 OS cells
MMP↓,
ER Stress↑, induction of various endoplasmic reticulum stress-related proteins and apoptotic proteins, including GRP78, GRP94, GADD153, ATF-6α, ATF-6β, caspase-4, caspase-12, calpain 1, caspase 3, and caspase 6 activity
GRP78/BiP↑,
CHOP/DDIT3↑,
ATF6↑,
angioG↓, Kaempferol could also induce anti-angiogenic potential, which is another major clinical challenge faced in cancer therapy.
VEGF↓, The marked decrease in the mRNA and protein levels of Vascular Endothelial Growth Factor (VEGF)
Hif1a↓, kaempferol, was also able to downregulate the expression of HIF-α (a regulator of VEGF)
chemoP↑, Interestingly, kaempferol also helps alleviate the serious adverse effects of standard chemotherapeutic agents.
*ROS↓, kaempferol reversed the vascular doxorubicin-induced vascular toxicity by reducing oxidative stress, i
NRF2↑, Kaempferol has been reported to activate Nrf2 and its downstream signaling pathways in multiple human cancer cell models, including MCF-7 breast cancer cells
BioAv↑, kaempferol gold nanoparticles (KAuNPs) using the reactive -OH group in the catechol ring of kaempferol and showed excellent biocompatibility with biological systems. They further observed a significant increase in the cytotoxic potential of KAuNP


Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

p‑AMT/GCST/T-protein↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   NRF2↑, 2,   ROS↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,   HK2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 2,   Casp9↑, 1,   hTERT/TERT↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   GRP78/BiP↝, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53?, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 2,   TIMP1↑, 1,   TIMP2↑, 1,   TumCP↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   Hif1a↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   ChemoSen↑, 1,   eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

hTERT/TERT↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 2,   neuroP↓, 1,   OS↑, 1,   toxicity∅, 1,  
Total Targets: 49

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   ROS↓, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↝, 1,   Inflam↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 2,   cognitive↓, 1,   hepatoP↓, 1,   hepatoP↑, 1,   neuroP↓, 5,   Risk↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 18

Scientific Paper Hit Count for: neuroP, neuroprotective
1 Astragalus
1 Aluminum
1 Chrysin
1 Hydrogen Gas
1 Helleborus niger extracts – Christmas Rose
1 Kaempferol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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