CA125 Cancer Research Results

CA125, CA125: Click to Expand ⟱
Source:
Type:
CA125 is a protein that is often measured in the blood as a tumor marker, primarily in the context of ovarian cancer.

-CA125 is most commonly used to monitor treatment response in patients already diagnosed with ovarian cancer and to detect its recurrence.
-It may be elevated in many cases of ovarian cancer, especially the epithelial type, making it a useful marker in certain clinical settings.
Scientific Papers found: Click to Expand⟱
2169- dietF,    Prolonged stabilization of platinum-resistant ovarian cancer in a single patient consuming a fermented soy therapy
- Case Report, Ovarian, NA
OS↑, Upon initiating self-directed treatment with Haelan951, a commercially available fermented soy beverage, she entered into a phase of prolonged disease stabilization including improvement in the serum tumor marker CA-125.
CA125↓,
eff↑, Fermented soy products are known to contain high concentrations of the isoflavone, genistein, and other compounds that exhibit anticancer activity in preclinical models.

2503- H2,    Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
- Case Report, Lung, NA
TumVol↓, Hydrogen-gas monotherapy was started to control the tumor a month later. After 4 months, the size of multiple brain tumors was reduced significantly
OS↑, After 1 year, all brain tumors had disappeared, and there were no significant changes in metastases in the liver and lung.
Dose↝, The hydrogen oxygen nebulizer (AMS-H-03, Asclepius Meditec, Shanghai, China) generates 3 L/min hydrogen gas by hydrocephalus electrolysis. As measured by gas chromatography, the gas generated consisted of 67% hydrogen and 33% oxygen.
Dose↝, Using a special mask, the patient continued to inhale hydrogen for 3–6 hrs a day at rest, with no interruption even after the obvious relief of symptoms.
CEA↓, dropped from 29.44 to 12 ng/mL in 12 months (figure 3)
CA125↓, dropped from 150 to 60 u/mL (figure 3)
CYFRA21-1↓, dropped from 12 to 6 ng/mL (figure 3)
SIRT1↓, several scholars have demonstrated that hydrogen can suppress SIRT1 signaling in different model
COX2/PTGS2↓, hydrogen exerts neuroprotective effects by reducing cyclooxygenase-2 activity25 or activating expression of anti-apoptotic protein kinase B.
IL1β↓, Hydrogen inhalation can down-regulate the expression of various pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, tumor necrosis factor-α, intracellular adhesion molecule-1, high mobility group box-1, nuclear factor-kappa B, and prosta
IL6↓,
TNF-α↓,
HMGB1↓,
NF-kB↓,
EP2↓, and prostaglandin-E2

7990- itraC,    A Novel Approach to Reducing Chemoresistance in Advanced Ovarian Cancer: The Effect of Itraconazole-A Single-Institution Randomized Placebo-Controlled Trial
- Trial, Ovarian, NA
Dose↝, itraconazole group received six chemotherapy cycles and 400 mg oral itraconazole for five days per cycle.
DCR↑, The objective response rate was 80% in the itraconazole group compared with 47% in the placebo group (p = 0.015), while the disease control rate was 100% versus 80%, respectively (p = 0.023).
PFS↑, Progression-free survival was significantly improved in the itraconazole group, with 70% of patients remaining progression-free compared with 26.7% in the placebo group
CA125↓, itraconazole group produced significant declines in the serum levels of CA-125 (p = 0.005) and p-glycoprotein (p = 0.042) with significant elevation in VEGFR-2 (p = 0.006) as compared to the control group.
P-gp/ABCB1↓,
VEGFR2/KDR/Flk1↑,
toxicity↓, Itraconazole was safe and its use was associated with a significant improvement in the quality of life (QOL).
QoL↑,
toxicity↝, no significant variations observed between the two study groups in the terms of reported adverse effect of the treatment including hematological toxicity such as anemia, neutropenia, thrombocytopenia, and non-hematological toxicity such as nausea, di

1714- Lyco,    Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load
- in-vitro, Ovarian, OV-MZ-6 - in-vivo, NA, NA
ChemoSen↑, Lycopene treatment synergistically enhanced anti-tumorigenic effects of paclitaxel and carboplatin
CA125↓, Lycopene decreased the expression of the ovarian cancer biomarker, CA125.
ITGA5↓, down-regulated expression of ITGA5, ITGB1, MMP9, FAK, ILK and EMT markers, decreased protein expression of integrin α5 and reduced activation of MAPK.
ITGB1↓,
MMP9↓,
FAK↓,
EMT↓,
MAPK↓,
MMP9↓, Levels of MMP9 in serum and ascites were reduced upon lycopene prevention
antiOx↑, The antioxidant properties of lycopene have been reported for the prevention and treatment of different tumor entities, especially in prostate cancer
Ki-67↓, expression of Ki67 in tumor tissues was lowered upon lycopene treatment compared to the placebo
MAPK↓, reduced the protein expression of integrin α5 and activation of MAPK signaling


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

DCR↑, 1,   PFS↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

MAPK↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   EP2↓, 1,  

Migration(tgid=13) ⓘ

CEA↓, 1,   FAK↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   Ki-67↓, 1,   MMP9↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   HMGB1↓, 1,   IL1β↓, 1,   IL6↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 3,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CA125↓, 4,   CEA↓, 1,   CYFRA21-1↓, 1,   IL6↓, 1,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 2,   QoL↑, 1,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 1,  
Total Targets: 34

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CA125, CA125
1 diet Fermented Foods
1 Hydrogen Gas
1 itraconazole
1 Lycopene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1176  State#:%  Dir#:1
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