miR-221 Cancer Research Results

miR-221, miR-221: Click to Expand ⟱
Source:
Type:
miR-221 (usually discussed together with miR-222) is a context-dependent, predominantly oncogenic microRNA that promotes cell-cycle progression, EMT, invasion, therapy resistance, and immune evasion in many cancers. Unlike miR-15/101/206, miR-221 is often overexpressed rather than lost.
-In Cancer: frequently upregulated
Scientific Papers found: Click to Expand⟱
5727- BF,    Bufalin Inhibits Proliferation and Induces Apoptosis in Osteosarcoma Cells by Downregulating MicroRNA-221
- in-vitro, OS, U2OS
TumCP↓, bufalin inhibited proliferation and induced mitochondria-dependent apoptosis in U-2OS and Saos-2 osteosarcoma cells with intracellular reactive oxygen species (ROS) production.
Apoptosis↑,
ROS↑,
miR-221↓, we found that miR-221 was downregulated after treatment with bufalin.

4707- CUR,    The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic Review
- Review, Var, NA
miR-497↑, Curcumin was found to cause the upregulation of miR-497, miR-200c, miR-200b, miR-409-3p, miR‐34, miR‐126, miR-145, miR-206, miR-491, miR-141, miR-429, miR-101, and miR-15a
miR-200c↑,
miR-409-3p↑,
miR-34a↑,
miR-126↑,
miR-145↑,
miR-206↑,
miR-491↑,
miR-141↑,
miR-429↑,
miR-101↑,
miR-15↑,
miR-21↓, and the downregulation of miR-21, miR-155, miR‐221, miR‐222, miR-17-5p, miR-130a, miR-27, and miR-20a.
miR-155↓,
miR-221↓,
miR-222↓,
miR-17↓,
miR-130a↓,
miR-27a-3p↓,
miR-20↓,

8113- LA,    Analyzing of colorectal cancer related genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines
- in-vitro, CRC, HT-29 - in-vitro, CRC, SW480
BAX↑, upregulation in the BAX, CASP3, and CASP9 and down regulation BCl-2, MMP2, and MMP9 genes
Casp3↑,
Casp9↑,
Bcl-2↓,
MMP2↓,
MMP9↓,
miR-34a↑, Also, a comparison of microRNA expression profiles indicated an increase of miR 34, 135, 25, 16, 195, 27, 98, let7 and a decrease of miR 9, 106b, 17, 21, 155, 221.
miR-25-5p↑,
miR-195↑,
miR-27a-3p↑,
Let-7↑,
miR-106b↓,
miR-17↓,
miR-21↓,
miR-155↓,
miR-221↓,
TumPF↓, The findings of this study indicate that probiotics can effectively suppress the proliferation of colorectal cancer cells and even reverse their development.


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-106b↓, 1,   miR-195↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   miR-497↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

miR-25-5p↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-145↑, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   miR-27a-3p↑, 1,   miR-409-3p↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Let-7↑, 1,   miR-101↑, 1,   miR-34a↑, 2,   miR-429↑, 1,  

Migration(tgid=13) ⓘ

miR-130a↓, 1,   miR-141↑, 1,   miR-155↓, 2,   miR-20↓, 1,   miR-200c↑, 1,   miR-206↑, 1,   miR-221↓, 3,   miR-222↓, 1,   miR-491↑, 1,   MMP2↓, 1,   MMP9↓, 1,   TumCP↓, 1,   TumPF↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

miR-126↑, 1,   miR-15↑, 1,   miR-17↓, 2,  
Total Targets: 35

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-221, miR-221
1 Bufalin/Huachansu
1 Curcumin
1 Lactobacillus
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1398  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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