MKK7 Cancer Research Results

MKK7, MAP2K7/MKK7: Click to Expand ⟱
Source:
Type:
MKK7 (also called MAP2K7) is a dual-specificity MAP kinase kinase that selectively activates the JNK (c-Jun N-terminal kinase) pathway. In cancer, MKK7 is a context-dependent stress signaling node that can drive apoptosis and tumor suppression or support adaptation, inflammation, and therapy resistance, depending on signal strength, duration, and cellular background.
Frequently dysregulated rather than simply up- or down-regulated
Observed patterns:
-Loss or suppression → reduced stress-induced apoptosis
-Chronic low-level activation → inflammation, survival signaling
MKK7 is a cell-fate switch, not a growth driver.
Cancer survives by blunting or reshaping MKK7–JNK signaling so that stress no longer triggers mitochondrial commitment to death. When MKK7 signaling is restored or sharpened, cancer cells often become highly vulnerable.
Scientific Papers found: Click to Expand⟱
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, Multiple licorice constituents have been shown to bind to and inhibit the activities of various cellular targets, including B-cell lymphoma 2, cyclin-dependent kinase 2, phosphatidylinositol 3-kinase, c-Jun N-terminal kinases, mammalian target of rap
CDK2↓,
PI3K↓,
cJun↓,
mTOR↓,
NF-kB↓, nuclear factor-κB, signal transducer and activator of transcription 3, vascular endothelial growth factor, and matrix metalloproteinase-3, resulting in reduced carcinogenesis in several in vitro and in vivo models with no evident toxicity
VEGF↓,
MMP3↓,
toxicity↓,
Dose↑, European Union established a temporary upper limit of 100 mg/day for glycyrrhizin consumption (about the amount found in 60–70 g licorice).
chemoP↑, Licorice has long been used as an antidote to counteract the toxicity of chemotherapeutic treatment
*antiOx↑, including antioxidant and anti-inflammatory properties, as well as a protective effect on several organs
*Inflam↓,
Dose↝, The main sweet-tasting ingredient of G. glabra (licorice) root is glycyrrhizin (or glycyrrhizinic acid or GA).
*COX2/PTGS2↓, glycyrrhizin and 18β-glycyrrhetinic acid have been defined by different investigators as significant inhibitors of inflammatory factors, such as cyclooxygenase-2 (COX-2), HMGP 1, inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), IL-10, t
*iNOS↓,
*IL6↓,
*IL10↓,
*PGE2↓, licochalcone A and licochalcone B inhibit IL-6 and PGE2 in LPS-induced macrophage cells,
*IκB?, isoliquiritigenin and isoliquiritin inhibit inhibitory κBα (IκBα) phosphorylation and degradation, and increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 in LPS-induced macrophage cells
*NRF2↑,
*HO-1↑,
*lipid-P↓, figure 2
*ROS↓,
*Catalase↑,
*GPx↑,
*SOD↑,
Apoptosis↑, The glycyrrhetinic acid and its derivatives induce mitochondrial-mediated apoptosis in cancer cells, as it was found in a study conducted by Lin et al119 where apoptosis was induced by the generation of reactive oxygen species (ROS)
ROS↑,
TumCP↓, GA, another flavonoid extracted from the roots of licorice also induces apoptosis and suppresses the proliferation of MDA-MB-231 breast cancer cells by increased generation of ROS.123
TumCCA↑, GA induces cell cycle arrest at G1/S phase in gastric cancer cells by downregulating the cyclin E1, cyclin E2, and cyclin D1-3 levels causing cell death in these cancer cells.
cycE/CCNE↓,
cycD1/CCND1↓,
p‑GSK‐3β↓, SK-MEL-28 and SK-MEL-5 Induced apoptosis ↓G1 phase, ↓cyclin D1, ↓cyclin E, ↓p-Akt, ↓p-GSK3β, ↓p-JNK1/2, ↓PI3K, ↓MKK4, ↓MKK7
PI3K↓,
MKK4↓,
MKK7↓,
HSP90↓, HT-29 Induced apoptosis ↓Proliferation, ↓viability of cells, ↑cell death of cancer cells, ↓HSP90
LC3‑Ⅱ/LC3‑Ⅰ↑, MKN28 Inhibited metastasis ↓Proliferation and metastasis, ↓migration and invasion, ↑LC3II/LC3I ratio, ↑Beclin 1, ↓p62, ↓p-Akt, ↓p- mTOR
Beclin-1/ATG6↑,
p62↓,
p‑Akt↓,
cl‑Casp9↑, Caki Induced apoptosis ↑Cleavage of caspase-9, caspase-7 and caspase-3, and PARP, ↑Bax, ↓Bcl-2, ↓ Bcl-xL, ↑cyt. c release, ↑p53, ↓MDM2, ↑ROS levels, ↓STAT3, ↓cyclin D1 and D2, ↓p-JAK2,
cl‑Casp7↑,
cl‑Casp3↑,
cl‑PARP↑,
BAX↑,
Cyt‑c↑,
P53↑,
STAT3↓,
E-cadherin↑, ↑E-cadherin ↓Vimentin, ↓N-cadherin,
Vim↓,
N-cadherin↓,
CD31/PECAM-1↓, ↓VEGF-A, ↓CD31 ↓HIF-1α, ↓iNOS, ↓COX-2
Hif1a↓,
iNOS↓,
DNAdam↑, ↑Nuclear condensation, ↑ nuclear fragmentation, ↑ apoptotic ratio, ↑decrease in the ΔΨ m, ↑Bax, ↑ Bim, ↑Apaf-1, ↑caspase-9, ↑caspase-3, ↓Bcl-2, ↑CDK2
MMP↓,
BIM↑,
APAF1↑,
PCNA↓, ↓PCNA, ↓MMP2, ↓ MMP9, ↑caspase-3, ↓p-PI3K, ↓p-Akt
toxicity↝, In addition, based on a case report, excessive consumption of licorice may also lead to toxic consequences in the form of thrombocytopenia.
eff↑, A clinical stage II preliminary trial revealed that licorice root extract in combination with docetaxel works in treating patients with hormonal therapy resistant metastatic prostate tumors

5187- PEITC,    Phenethyl Isothiocyanate Inhibits Migration and Invasion of Human Gastric Cancer AGS Cells through Suppressing MAPK and NF-κB Signal Pathways
- in-vitro, GC, AGS
TumMeta↓, PEITC can inhibit migration and invasion through the extracellular signal-regulated kinases 1/2 (ERK1/2), protein kinase C (PKC) and nuclear factor-kappaB (NF-κB) signaling pathways in human gastric cells.
ERK↓, PEITC exerted an inhibitory effect on the ERK1/2, mitogen-activated protein kinase kinase 7 (MKK7)
MKK7↓,
PKCδ↓, PKC, Ras homolog gene family, member A (Rho A) and urokinase-type plasminogen activator (uPA), causing the inhibition of matrix metallopeptidase-2 (MMP-2) and -9
Rho↓,
uPA↓,
MMP2↓,
MMP9↓,
RAS↓, PEITC also inhibited Ras, growth factor receptor-bound protein 2 (GRB2), vascular endothelial growth factor (VEGF), focal adhesion kinase (FAK), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), causing inhibition of cell prolifera
VEGF↓,
FAK↓,
iNOS↓,
COX2/PTGS2↓,
TumCP↓,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MKK4↓, 1,   MKK7↓, 2,   MMP↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   BIM↑, 1,   cl‑Casp3↑, 1,   cl‑Casp7↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   iNOS↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   p‑GSK‐3β↓, 1,   mTOR↓, 1,   PI3K↓, 2,   RAS↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

CD31/PECAM-1↓, 1,   E-cadherin↑, 1,   FAK↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   PKCδ↓, 1,   Rho↓, 1,   TumCP↓, 2,   TumMeta↓, 1,   uPA↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↑, 1,   Dose↝, 1,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   toxicity↓, 1,   toxicity↝, 1,  
Total Targets: 57

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL10↓, 1,   IL6↓, 1,   Inflam↓, 1,   IκB?, 1,   PGE2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 16

Scientific Paper Hit Count for: MKK7, MAP2K7/MKK7
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1441  State#:%  Dir#:1
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