SALL4 Cancer Research Results

SALL4, SALL4: Click to Expand ⟱
Source:
Type:

SALL gene family involved in tumorigenesis. transcriptional regulators of the‏ stem cells. SALL4 is the most well studied SALL gene‏ associated with the cancer. SALL4 is highly‏ expressed in several solid tumors (BC HCC, GC, colon)
Scientific Papers found: Click to Expand⟱
6130- CHr,    Anticancer Properties of Chrysin on Colon Cancer Cells, In vitro and In vivo with Modulation of Caspase-3, -9, Bax and Sall4
- vitro+vivo, Colon, CT26
tumCV↓, chrysin exerted a cytotoxic effect on CT26 cells in a dose dependent manner with IC50= 80 μg.mL-1
Apoptosis↑, chrysin administrated cytotoxicity on colon cancer cells through recruitment of the apoptosis.
TumVol↓, The in vivo assay revealed a remarkable reduction of the colon tumor volume in treated mice (8, 10 mg.kg -1) as compared to the untreated mice.
BAX↑, through down regulation of the sall4 and up-regulation of the Bax.
SALL4↓,
Casp3↑, increase in‏ the caspase-3 and caspase-9 activity in the treated cells‏ in a concentration-dependent manner as compared with‏ the control cells.
Casp9↑,
ChemoSen↑, Recently, a synergism between doxorubicin and chrysin‏ administrated cancer cell death has been shown through‏ chemosensitizing these cells to chemotherapy via GSH‏ depletion in the cancer cells (27).
GSH↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

SALL4↓, 1,  

Redox & Oxidative Stress ⓘ

GSH↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Casp3↑, 1,   Casp9↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SALL4, SALL4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1469  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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