HSPD1 / HSP60 Cancer Research Results

HSPD1 / HSP60, HSPD1 = HSP60 / mitochondrial chaperonin 60: Click to Expand ⟱
Source:
Type:

high HSPD1/HSP60 supports tumor survival, mitochondrial proteostasis, metabolism, apoptosis resistance, invasion, and therapy tolerance. But in some settings, reduced HSPD1 can also worsen tumor behavior, so direction must be considered with cancer type/model.
Scientific Papers found: Click to Expand⟱
6160- Cin,    Cinnamaldehyde induces apoptosis and enhances anti-colorectal cancer activity via covalent binding to HSPD1
- vitro+vivo, CRC, HCT116
AntiTum↑, Herein, we found that cinnamaldehyde (CA) could exert an antitumor effect in HCT-116 cell lines.
Apoptosis↑, CA could induce cell apoptosis by inhibiting the PI3K/Akt signaling pathway and enhanced anti-CRC activity both in vitro and in vivo.
PI3K↓,
Akt↓,
TumCG↓, CA inhibited HCT-116 cells growth
TumCCA↑, CA-induced apoptosis and arrested the G0/G1 phase in HCT-116 cells
HSPD1 / HSP60↓, This study showed that CA could covalently bind with HSPD1 and exert an anti-CRC effect.
Ki-67↓, There was obvious decrease of Ki67-positive cells in “CA” groups
ChemoSen↑, Our results showed that among the anti-CRC chemotherapeutic agents commonly used during clinical practice (TAX, Pt, 5-FU, and OX), the combination of CA and 5-FU exhibited the best synergistic effect in vitro


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

HSPD1 / HSP60↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,   TumCG↓, 1,  

Migration ⓘ

Ki-67↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HSPD1 / HSP60, HSPD1 = HSP60 / mitochondrial chaperonin 60
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1472  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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