VEGFR1 Cancer Research Results

VEGFR1, vascular endothelial growth factor receptor 1: Click to Expand ⟱

Source:

Type:

VEGFR1 / FLT1 is a VEGF-family receptor involved in angiogenesis, tumor microenvironment signaling, myeloid/macrophage recruitment, tumor-cell migration/survival, metastasis, and pre-metastatic niche formation. In cancer, membrane VEGFR1 activation is generally pro-cancer, while VEGFR1 inhibition is generally anti-angiogenic and anti-metastatic.

Scientific Papers found: Click to Expand⟱

6271-

DL,

D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells

in-vitro,

Colon,

SW480

100μg/ml

in-vitro,

Colon,

HT-29

TumCP↓, BVOE exhibited dose-dependent inhibition of cell proliferation and induced apoptosis in the colon cancer cells,
Apoptosis↑,
Bax:Bcl2↑, BVOE shows dose-dependent induction of Bax/Bcl2) and inhibition of vascular endothelial growth factor (VEGF).
VEGF↓,
angioG↓, BVOE suggested the inhibition of VEGF and markers associated with inhibition of angiogenesis.
TumMeta↓, Dose-dependent anti-metastasis activity and blockage of vascular endothelial growth factor receptor 1 (VEGFR1) binding following treatment with BVOE
VEGFR1↓,
MMP9↓, decreased expression of matrix metalloproteinases (MMP-9)

6336-

Eug,

Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG

in-vivo,

GC,

rats

Apoptosis?, Rats administered MNNG developed gastric carcinomas that displayed apoptosis avoidance coupled to upregulation of pro-invasive and angiogenic factors
Bcl-2↓, Administration of eugenol induced apoptosis via the mitochondrial pathway by modulating the Bcl-2 family proteins, Apaf-1, cytochrome C, and caspases and inhibiting invasion, and angiogenesis
Cyt‑c↝,
Casp↑,
TumCI↓,
angioG↓,
MMPs↓, as evidenced by changes in the activities of MMPs and the expression of MMP-2 and -9, VEGF, VEGFR1, TIMP-2 and RECK.
VEGF↓,
VEGFR1↓,
TIMP2↑, Administration of eugenol decreased activities of MMPS and the expression of MMP-2, MMP-9, VEGF and VEGFR1 and increased TIMP-2 and RECK expression
RECK↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis?, 1, Apoptosis↑, 1, Bax:Bcl2↑, 1, Bcl-2↓, 1, Casp↑, 1, Cyt‑c↝, 1,

Migration ⓘ

MMP9↓, 1, MMPs↓, 1, RECK↑, 1, TIMP2↑, 1, TumCI↓, 1, TumCP↓, 1, TumMeta↓, 1, VEGFR1↓, 2,

Angiogenesis & Vasculature ⓘ

angioG↓, 2, VEGF↓, 2,
Total Targets: 16

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: VEGFR1, vascular endothelial growth factor receptor 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells