TK1 Cancer Research Results

TK1, thymidine kinase 1: Click to Expand ⟱
Source:
Type:
Scientific Papers found: Click to Expand⟱
6563- Ger,  5-FU,    Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts
- vitro+vivo, Colon, SW-620 - in-vitro, Colon, Caco-2
TS↓, Geraniol (150 microM) but not 5-fluorouracil caused a 2-fold reduction of thymidylate synthase and thymidine kinase expression in cancer cells.
TK1↓,
ChemoSen↑, potentiates 5-fluorouracil efficacy
TumVol↓, combined administration of 5-fluorouracil (20 mg/kg) and geraniol (150 mg/kg) caused a 53% reduction of the tumor volume, whereas a 26% reduction was obtained with geraniol alone, 5-fluorouracil alone showed no effect.
OS↑, when geraniol and 5-FU were administered in combination the survival of mice was increased by 1.5 to 2-fold when compared to controls.

8097- KAE,    The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells
- in-vitro, CRC, LS174T
ChemoSen↑, Our results showed that only Kaempferol was able to chemo-sensitize 5-FU-resistant LS174-R cells.
tumCV↓, This phenolic compound combined with 5-FU exerted synergistic inhibitory effect on cell viability.
Apoptosis↑, combination enhanced the apoptosis and induced cell cycle arrest of both chemo-resistant and sensitive cells through impacting the expression levels of different cellular effectors.
TumCCA↑,
ROS↓, Kaempferol also blocked the production of reactive oxygen species (ROS) and modulated the expression of JAK/STAT3, MAPK, PI3K/AKT and NF-κB
Casp3↑, activation of caspase 3 and caspase 9 and cleavage of PARP
Casp9↑,
cl‑PARP↑,
p‑STAT3↓, Kaempferol alone or combined with 5-FU reduced the phosphorylated form of STAT3 and the one of the pro-survival kinase AKT and its target tumor suppressor FOXO3a transcription factor,
Akt↓,
FOXO3↓,
NF-kB↓, Our result also supports the inhibition of NF-κB in the refractive cancer cell line model
VEGF↓, interestingly, the combined treatment reduced also the production of VEGF-A (from 707 to 308 pg/ml) and IL-8 (from 319 to 127 pg/ml)
TS↓, TS and TK in the 5-FU-resistant cells, compared to sensitive LS174 cells (Fig. 7c), while the Kaempferol alone or in combination with 60 µM of 5-FU decreased the expression of the two proteins
TK1↓,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

TS↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Casp3↑, 1,   Casp9↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO3↓, 1,   p‑STAT3↓, 1,   TK1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 2,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,   TumVol↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TK1, thymidine kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1503  State#:%  Dir#:1
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