PLA2 Cancer Research Results

PLA2, Phospholipase A2: Click to Expand ⟱
Source:
Type:

PLA2 - Phospholipase A2

Abbreviation: PLA2

Type: Phospholipase / lipid-metabolizing enzyme family

Function: Hydrolyzes the sn-2 fatty-acid bond of membrane phospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids. PLA2 activity regulates eicosanoid production, inflammation, membrane remodeling, cell signaling, proliferation, and oxidative responses.

Cancer: ↑ Generally increased/pro-tumorigenic for several important PLA2 isoforms, particularly cPLA2α (PLA2G4A) and selected secreted PLA2 enzymes. Increased PLA2 signaling can promote arachidonic-acid/eicosanoid production, inflammation, angiogenesis, tumor growth, invasion, metastasis, and tumor-microenvironment signaling.

Alzheimer's Disease: ↑ Increased or overactivated cPLA2/arachidonic-acid signaling has been associated with Aβ-induced neurotoxicity, neuroinflammation, synaptic dysfunction, and cognitive impairment.
Scientific Papers found: Click to Expand⟱
7260- Gink,    Ginkgetin: A natural biflavone with versatile pharmacological activities
- Review, Var, NA - Review, Stroke, NA - Review, AD, NA
*AntiCan↑, *Inflam↓, *AntiBio↑, *neuroP↑, *TumCCA↑, Apoptosis↑, TumAuto↑, iNOS↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PLA2↓, *neuroP↑, *Stroke↓, *AntiFungal↓, *Bacteria↓, Bcl-xL↓, Bcl-2↓, Casp9↑, Casp3↑, cl‑PARP↑, IL6↓, STAT3↓, JAK1↓, survivin↓, COX2/PTGS2↓, IAP1↓, MMP2↓, MMP9↓, PTEN↑, SHP1↑, eff↑, TumVol↓, TumW↓, *toxicity↓, *ROS↓,
7954- RT,    Rutin : therapeutic potential and recent advances in drug delivery
- Review, Nor, NA - Review, IBD, NA
*antiOx↑, *antiAll↑, *Inflam↓, *AntiTum↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *AntiArt↑, *PLA2↓, *chemoP↑, *ROS↓, *Casp3↓, *TNF-α↓, *NF-kB↓, *cardioP↑, *Stroke↓, *TG/TAG↓, *FFA/NEFA↓, *LDL↓, *HDL↑, *AntiDiabetic↑, *MPO↓, *NF-kB↓, *BioAv↓, *BioAv↝,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

PLA2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   Casp9↑, 1,   IAP1↓, 1,   iNOS↓, 1,   survivin↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PTEN↑, 1,   SHP1↑, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL6↓, 1,   JAK1↓, 1,   NF-kB↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,   TumW↓, 1,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

antiAll↑, 1,   AntiArt↑, 1,   AntiBio↑, 1,   FFA/NEFA↓, 1,   PLA2↓, 1,   Stroke↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   HDL↑, 1,   MPO↓, 1,   ROS↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,   NF-kB↓, 2,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 1,   neuroP↑, 2,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↓, 1,   AntiViral↑, 1,   Bacteria↓, 2,  
Total Targets: 29

Scientific Paper Hit Count for: PLA2, Phospholipase A2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1615  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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