Mucositis Cancer Research Results
Mucositis, Mucositis: Click to Expand ⟱
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| Type: |
| Mucositis is a very painful unavoidable and common side effect in head and neck cancer patients undergoing curative radiotherapy
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Scientific Papers found: Click to Expand⟱
Mucositis↓, when compared with iodine alone, the group where iodine and amla gargling were used was very effective in delaying mucositis, reduced incidence of intolerable mucositis
Dose↝, Amla also contains gallic acid, ellagic acid, chebulinic acid, chebulagic acid, emblicanin-A, emblicanin-B, punigluconin, pedunculagin, ellagotannin, trigallayl glucose, chebulagic acid, corilagin and isostrictiniin.
Dose↝, Amla also has a high level of flavonoids like quercetin, kaempferol 3 O alpha L (6″ methyl) rhamnopyranoside and kaempferol 3 O alpha L (6″ ethyl) rhamnopyranoside [4].
*Bacteria↓, Scientific investigations have shown that amla possesses antibacterial, antifungal, and antiviral properties.
*AntiFungal↑,
*AntiViral↑,
*hepatoP↑, Amla also has anti-tussive, anti-atherogenic, hypolipidemic, hepatoprotective, renoprotective, and neuroprotective properties
*RenoP↑,
*neuroP↑,
Dose↝, Briefly, 1% amla mouthwash was prepared by dissolving 1 g of dried amla powder in 100 ml of hot water with vigorous stirring.
Dose↝, Test group (15 patients) received oral bLF 250 mg/day beside chemotherapy for three months. Control group (15 patients) received chemotherapy only.
toxicity↓, 3 months after treatment indicates that no significant difference in mean values of serum creatinine, AST, ALT, serum LF, serum GST enzyme, INF-γ, WBCs count, platelet count, CEA, RBCs count, neutrophil count, and Hb level of patients
INF-γ↝, Mean percent of change of main parameters (serum LF, serum GST enzyme, and INF-γ) after than before treatment among the studied patients indicate significant improvement in patients who received oral bLF 3 months
other↑, The results of this trial indicate that oral bLF made a significant increase in serum LF levels of patients in the test group 3 months after treatment compared to patients in the control group (P ≤ 0.05).
*ROS↓, Iron is essential as a catalyst for the production of reactive oxygen species. Therefore, lactoferrin can diminish the harmful influence of reactive oxygen species produced by leukocytes at the sites of inflammation
Imm↑, This result indicates that oral bLF enhances the immune system of colorectal cancer patients.
WBC↑, As a result of this increase in WBCs and neutrophil count patients disease state may be improved, because the body immune system can fight the disease more efficiently compatible with some previous studies
Neut↑,
T-Cell↑, These results support the proposal that oral supplements of bovine lactoferrin may be a useful adjunct toward modulation of immune activity, in particular T-cell activation and antioxidant status
*antiOx↑, The effect of antioxidants such as LF increase intracellular glutathione (GSH) levels in vascular endothelial cells by modulation of the GSH redox
*GSH↑,
*chemoP↑, On the other hand, oral bLF administration decreased chemotherapy related side effects as it enhances both renal and hepatic function tests.
*RenoP↑, Also, LF decreased chemotherapy related side effects by protecting liver and kidney from toxicity and improving their function test values
*hepatoP↑, Oral lactoferrin may increase liver functions and protect it from damage by reactive oxygen species since LF can function as an antioxidant, reducing intracellular levels of ROS
BUN↓, mean serum BUN decreased from 16.23 mg/dL before treatment to 11.43 mg/dL after 3 months of treatment in patients in the test group
creat↓, This decrease in BUN and serum creatinine may be due to the antioxidant effect of LF as mentioned in a former preclinical study on rat model of ferric nitrilotriacetate- (Fe-NTA-) induced renal tubular oxidative injury.
ALAT↓, Also, there was a significant decrease in serum ALT and AST in patients in test group 3 months after treatment compared to patients in the control group
AST↓,
RBC↑, Oral bLF administration enhanced anemia which is a very common chemotherapy related side effect; as results have shown, there were significant increases in RBCs count and serum Hb in patients in test group 3 months after treatment compared to patient
PC↑, There was a significant increase in platelets count in patients in test group after 3 months compared to control group
Mucositis↓, Patients in test group had less severed mucositis than patients in control group after every chemotherapy cycle;
*AntiBio↑, As mentioned before, lactoferrin has protective effects that range from direct antimicrobial activities against a large panel of microorganisms, including bacteria, viruses, fungi, and parasites, to anti-inflammatory and anticancer activities [
*AntiViral↑,
*AntiFungal↑,
*Inflam↓,
Showing Research Papers: 1 to 2 of 2
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2
Pathway results for Effect on Cancer / Diseased Cells:
NA, unassigned(tgid=0) ⓘ
Mucositis↓, 2, PC↑, 1, RBC↑, 1, WBC↑, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
ALAT↓, 1, BUN↓, 1,
Transcription & Epigenetics(tgid=7) ⓘ
other↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
Imm↑, 1, INF-γ↝, 1, Neut↑, 1, T-Cell↑, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
Dose↝, 4,
Clinical Biomarkers(tgid=22) ⓘ
ALAT↓, 1, AST↓, 1, creat↓, 1,
Functional Outcomes(tgid=23) ⓘ
toxicity↓, 1,
Total Targets: 16
Pathway results for Effect on Normal Cells:
NA, unassigned(tgid=0) ⓘ
AntiBio↑, 1,
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 1, GSH↑, 1, ROS↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
Inflam↓, 1,
Functional Outcomes(tgid=23) ⓘ
chemoP↑, 1, hepatoP↑, 2, neuroP↑, 1, RenoP↑, 2,
Infection & Microbiome(tgid=24) ⓘ
AntiFungal↑, 2, AntiViral↑, 2, Bacteria↓, 1,
Total Targets: 12
Scientific Paper Hit Count for: Mucositis, Mucositis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:1640 State#:% Dir#:1
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