Aβ42 Cancer Research Results

Aβ42, Amyloid Beta 1-42: Click to Expand ⟱
Source:
Type:

Aβ42 - Amyloid Beta 1-42

Type: Amyloid peptide / Alzheimer's disease pathological protein / biomarker

Function: Aβ42 is a 42-amino-acid amyloid-beta peptide generated from amyloid precursor protein (APP) through sequential cleavage by β-secretase and γ-secretase. Compared with shorter Aβ species such as Aβ40, Aβ42 is more hydrophobic and aggregation-prone and readily forms oligomers, fibrils, and amyloid plaques.

Alzheimer's Disease: ↑ in aggregated brain deposits / ↓ in soluble CSF. Aβ42 is a major component of cerebral amyloid plaques and its aggregation is a defining feature of Alzheimer's disease pathology. Increased accumulation of oligomeric and fibrillar Aβ42 is associated with synaptic dysfunction, neuroinflammation, oxidative stress, and neuronal injury. In contrast, soluble CSF Aβ42 typically decreases as cerebral amyloid deposition increases, and a reduced CSF or plasma Aβ42/Aβ40 ratio is used as a biomarker of amyloid pathology.
Scientific Papers found: Click to Expand⟱
8220- LCA,    Licochalcone a enhances cognitive resilience in APP/PS1 Mice by modulating glucose metabolism, Aβ burden, and neuroinflammation
- in-vivo, AD, NA
*Dose↝, mice received intraperitoneal LCA (15 mg·kg-1·day-1) treatment for 4 weeks. A
*memory↑, LCA significantly improved long-term memory in APP/PS1 mice, through MWM and NORT
*PSD95↑, upregulated PSD95 and spinophilin levels, and enhanced Ki67-positive cells in the hippocampus.
*Ki-67↑,
*GLUT1↑, LCA treatment ameliorated glucose tolerance and initial insulin response while increasing Insr expression and GLUT1 protein levels.
*Aβ↓, LCA-treated APP/PS1 mice showed reduced plaque burden and Aβ42 levels.
*Aβ42↓,
*Inflam↓, LCA demonstrated its anti-inflammatory effect by reducing glial reactivity, and Trem2 expression.
*TREM2↓,
*cognitive↑, ultimately enhancing cognitive resilience

8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, Lactoferrin (LF), a glycoprotein with strong iron chelating properties, can regulate its availability to cancer cells, thereby limiting their growth and progression.
ROS↓, By chelating free Fe ions, LF reduces oxidative stress and inhibits the mechanisms that promote carcinogenesis.
Imm↑, Additionally, it exhibits immunomodulatory and anti-inflammatory effects and may enhance the body’s anti-tumor response.
Inflam↓,
*BBB↑, LF crosses from the blood into the cerebrospinal fluid through the blood–brain barrier [25], where its beneficial effects have been documented in the context of neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, and de
Iron↝, Among the many biological properties of lactoferrin, its ability to strongly bind and transport iron ions over a wide range of pH values is a key function, determining its effectiveness in regulating iron homeostasis
*Fenton↓, LF, due to its ability to chelate iron, reduces its availability for the Fenton reaction, which reduces oxidative stress
*ROS↓,
*TAC↑, antioxidant properties of LF supplementation resulted in an increase in hydrophilic antioxidant capacity [151], a decrease in oxidative stress markers [152,153], and an increase in total antioxidant status (TAS)
*SOD↑, It also improved the levels of antioxidant markers, such as SOD, GPx, and glutathione, compared with the placebo group
*GPx↑,
*GSH↑,
*TBARS↓, Supplementation with LF-containing colostrum led to lower levels of thiobarbituric acid reactive substances (TBARS).
*PTEN↓, In addition, in patients with Alzheimer’s disease, LF supplementation led to the decreased expression of phosphatase and tensin homolog (PTEN), tau, and mitogen-activated protein kinase (MAPK1), as well as decreased serum levels of Aβ42, which ma
*tau↓,
*MAPK↓,
*Aβ42↓,
*Apoptosis↓, Reducing hydrogen peroxide-induced apoptosis through the inhibition of caspase-3 and Akt activation
*Casp3↓,
*Akt↑,
*GutMicro↑, LF shows a beneficial effect on the composition of the microbiota, promoting the growth of beneficial bacteria such as Bifidobacterium and Lactobacillus, while inhibiting the growth of pathogens such as Escherichia coli, Salmonella, and Shigella.
*Sepsis↓, A meta-analysis suggests that it may reduce the risk of fungal sepsis and shorten the hospitalization of preterm infants
*anemia↓, LF administration is a promising therapy for iron deficiency (ID) conditions, including iron deficiency anemia (IDA), both as a primary treatment and as an adjunctive therapy.
*IL6↓, ability to inhibit interleukin-6 (IL-6) expression, LF decreases hepcidin synthesis, which in turn increases ferroportin levels, restoring iron export from cells to the blood i
*FPN↑,
*TfR1/CD71↑, In addition, LF induces an increase in transferrin receptor 1 (TfR1) levels and a decrease in ferritin (Ftn) levels
*Ferritin↓,
*HemoG↑, Numerous intervention studies have confirmed the efficacy of LF supplementation, showing an increase in hemoglobin (Hb), total iron, erythrocyte count (RBC), and serum ferritin levels.
*RBC↑,
*eff↑, Most studies have shown similar or superior efficacy of bLF to traditionally used therapy (ferrous sulfate and ferric hydroxide) in restoring iron deficiency, with significantly fewer gastrointestinal side effects
*BioAv↓, Orally administered LF has low bioavailability due to degradation at unfavorable gastric pH and by proteolytic enzymes in the intestinal lumen and poor permeability through the intestinal epithelium, which limits its effective delivery to target site
*BioAv↑, LF is much better absorbed when administered directly into the duodenum. Therefore, ... coating enteral capsules containing LF, encapsulating it in nanocarriers, which allows it to be released at a site with less gastric pepsin activity
*BioAv↝, Other routes of administration, including transdermal or inhalation, are also being considered, which could avoid degradation in the gastrointestinal tract.
*ChemoSen↑, studies suggest that LF may act synergistically with other therapies such as chemotherapy, immunotherapy, and targeted therapy
*BioAv↑, Additionally, the use of probiotic bacteria as internal producers of LF in the body may open new perspectives for its therapeutic use.
Ferroptosis↑, LF also induces ferroptosis—iron-dependent cell death, which leads to excessive lipid oxidation in cell membranes and the destruction of cancer cells.

8144- LF,    A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway
- Human, AD, NA
*Ach↑, AD patients showed decreased serum (ACh), (5-HT), antioxidant and anti-inflammatory markers, and decreased expression of Akt.., as well as PI3K, and p-Akt levels in PBL lysate; all these parameters were significantly improved after daily LF administr
*5HT↑,
*TAC↑,
*Inflam↓,
*Akt↑,
*PI3K↑,
*Aβ42↓, elevated serum amyloid β (Aβ) 42, cholesterol, oxidative stress markers, IL-6, heat shock protein (HSP) 90, caspase-3, and p-tau, as well as increased expression of tau, MAPK1 and PTEN in AD patients, were significantly reduced upon LF intake.
*LDL↓,
*ROS↓,
*IL6↓,
*HSP90↓,
*Casp3↓,
*tau↓,
*MAPK↓,
*PTEN↓,
*cognitive↑, reflected in enhanced cognitive function assessed by the Mini-Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale-Cognitive Subscale 11-item (ADAS-COG 11) questionnaires as clinical endpoints.
*Dose↝, received either standard therapy (group 1, AD patients without LF) or LF capsules (Jarrow Formulas®, USA, 250 mg/day, p.o.; group 2) [26] for three months.

7825- LT,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, neuroprotective activity of luteolin was also observed in a transgenic Drosophila model.
*OS↑, showed that luteolin extend the life span of Drosophila, enhanced its antioxidative ability, and directly bound to Aβ42 and AChE to inhibit the Aβ aggregation and cholinergic deficits
*antiOx↑,
*Aβ42↓,
*AChE↓,
*Aβ↓,
*IRes↓, It was found that luteolin (50 mg/kg) reduced cerebral insulin resistance and tau hyperphosphorylation in a high fat diet (HFD
*p‑tau↓,
*ROS↓, neuroprotective activity in AD was achieved by inhibition of oxidative stress, apoptosis, neuroinflammation, AChE activity, cerebral insulin resistance, or iron imbalance.
*Apoptosis↓,
*Inflam↓,
*Iron↝,


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   Iron↝, 1,   ROS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,   Inflam↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

anemia↓, 1,   Aβ42↓, 4,   FPN↑, 1,   IRes↓, 1,   RBC↑, 1,   TREM2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Fenton↓, 1,   GPx↑, 1,   GSH↑, 1,   Iron↝, 1,   ROS↓, 3,   SOD↑, 1,   TAC↑, 2,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   TfR1/CD71↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,   Apoptosis↓, 2,   Casp3↓, 2,   MAPK↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↑, 1,   PTEN↓, 2,  

Migration(tgid=13) ⓘ

Ki-67↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 2,   Inflam↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   PSD95↑, 1,   tau↓, 2,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 1,   Dose↝, 2,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ferritin↓, 1,   GutMicro↑, 1,   HemoG↑, 1,   IL6↓, 2,   Ki-67↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 2,   memory↑, 1,   neuroP↑, 1,   OS↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 53

Scientific Paper Hit Count for: Aβ42, Amyloid Beta 1-42
2 Lactoferrin/Talactoferrin
1 Licochalcone A
1 Luteolin
1 Mung Bean Sprouts
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1706  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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