SERPINH1/HSP47 Cancer Research Results

SERPINH1/HSP47, Serpin Family H Member 1 / Heat Shock Protein 47: Click to Expand ⟱
Source:
Type:

SERPINH1 - Serpin Family H Member 1 / Heat Shock Protein 47

Abbreviation: SERPINH1, HSP47

Alternative Names: Hsp47, Colligin, Collagen-Binding Protein

Type: Endoplasmic-reticulum molecular chaperone / collagen-specific chaperone

Function: HSP47 is an endoplasmic-reticulum-resident molecular chaperone that specifically binds procollagen and facilitates correct collagen folding, triple-helix formation, maturation, and secretion. It is particularly important for extracellular-matrix and fibrotic collagen production.

Cancer: ↑ Frequently increased in multiple cancers and tumor-associated stroma. Elevated HSP47 can promote collagen maturation and extracellular-matrix deposition and has been associated with tumor growth, angiogenesis, migration, invasion, metastasis, and poor prognosis. HSP47 inhibition can reduce collagen-dependent tumor-supportive processes in experimental models.
Scientific Papers found: Click to Expand⟱
8075- KAE,  QC,    Systematic review on anticancer potential of Kaempferol and quercetin against lung, breast, and colorectal cancers with emphasis on in vitro and in vivo studies
- Review, Var, NA
tumCV↓, Both compounds consistently reduced cancer cell viability, induced apoptosis.
Apoptosis↑,
TumCP↓, They inhibited proliferation and migration by modulating the PI3K/Akt, MAPK, NF-κB, and p53 pathways across breast, lung, and colorectal cancer cell lines.
TumCMig↓,
PI3K↓,
Akt↓,
MAPK↓,
NF-kB↓,
P53↑,
Bcl-2↓, Bcl-2 downregulation and cleaved PARP activation
PARP↑,
ERK↓, kaempferol induce apoptosis by suppressing ERK1/2 pathway via IQGAP3 inhibition as well as by elevating γH2AX, cleaved caspase-3 and − 9 expression
IQGAP3↓,
γH2AX↑,
cl‑Casp3↑,
cl‑Casp9↑,
Rho↓, It reduced RhoA and Rac1 activity in MDA-MB-231 cells and countered triclosan-induced migration in MCF-7 cells by downregulating MMP-2/9 and cathepsins B and D
Rac1↓,
MMP2↓,
MMP9↓,
CTSB↓,
CTSD↓,
O-Glc↓, suppresses O-GlcNAcylation and Hsp47
SERPINH1/HSP47↓,
EMT↓, Inhibition of metastasis and epithelial-mesenchymal transition (EMT)
angioG↓, It suppresses tumor-induced angiogenesis in colorectal cancer by downregulating EGF-A/VEGFR2 pathway
EGF↓,
VEGFR2/KDR/Flk1↓,
RadioS↑, Quercetin showed anti-proliferative activity against the lung cancer cells by radio-sensitization and targeting the apoptotic mechanism.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IQGAP3↓, 1,   O-Glc↓, 1,   SERPINH1/HSP47↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   PARP↑, 1,   γH2AX↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CTSB↓, 1,   CTSD↓, 1,   EMT↓, 1,   ERK↓, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,   Rac1↓, 1,   Rho↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

RadioS↑, 1,  
Total Targets: 29

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SERPINH1/HSP47, Serpin Family H Member 1 / Heat Shock Protein 47
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1756  State#:%  Dir#:1
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