APOE4 Cancer Research Results

APOE4, Apolipoprotein E ε4 Allele / ApoE4 Isoform: Click to Expand ⟱
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Type:

APOE4 - Apolipoprotein E ε4 Allele / ApoE4 Isoform

Canonical Gene: APOE

Abbreviation: APOE4, APOE ε4, ApoE4

Type: Genetic variant / protein isoform / Alzheimer's disease risk factor

Function: APOE encodes apolipoprotein E, a lipid-transport protein involved in cholesterol trafficking, neuronal maintenance, synaptic repair, immune regulation, and cerebrovascular function. The APOE ε4 allele produces the ApoE4 isoform, which differs structurally and functionally from ApoE2 and ApoE3.

Alzheimer's Disease: ↑ APOE ε4 is the strongest common genetic risk factor for late-onset Alzheimer's disease. ApoE4 promotes amyloid-β accumulation and impaired clearance, tau pathology, neuroinflammation, lipid and cholesterol dysregulation, mitochondrial dysfunction, synaptic impairment, blood-brain barrier dysfunction, and increased neuronal vulnerability.

Favorable Direction in Alzheimer's Disease: ↓ ApoE4-associated pathogenic activity or conversion toward a more ApoE3-like functional state is generally favorable. APOE ε4 carriage itself is a fixed genetic factor, so therapeutic strategies typically target ApoE4 expression, structure, lipidation, receptor interactions, or downstream pathways rather than reducing the allele itself.

Cancer: ↕ Context-dependent. APOE can influence tumor immunity, lipid metabolism, angiogenesis, and tumor-microenvironment interactions, but APOE ε4 is not a consistent universal cancer-promoting or cancer-suppressing factor across malignancies.
Scientific Papers found: Click to Expand⟱
8145- LF,    Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review
- Review, AD, NA - Review, Park, NA
*AntiBio↑, Recent advancements in lactoferrin research have uncovered that lactoferrin does function not only as an antimicrobial protein but also as an immunomodulatory, anticancer, and neuroprotective agent.
*Imm↑,
*AntiCan↑,
*neuroP↑,
*BBB↑, Lactoferrin has been shown to cross the blood−brain barrier (BBB)
*APOE4↓, mainly via three mechanisms: (i) inhibiting apolipoprotein 4 (APOE4), (ii) promoting nonamyloidogenic pathway, and (iii) suppressing oxidative stress, inflammation, and apoptosis.
*ROS↓,
*Inflam↓,
*Apoptosis↓,
*Learn↑, In the APP/PS1 transgenic mouse model of AD, Guo et al.95 showed that lactoferrin treatment improved spatial learning and decreased amyloid plaques in the hippocampus and cortex.
*memory↑,
*ADAM10↑, by upregulating enzymatic activities of ADAM10 and PS1 to promote the nonamyloidogenic cleavage of APP.
*PSEN1/PS1↑,
*cl‑APP↑,
*BACE/β-secretase↓, In this study, lactoferrin also increased sAPPα and decreased sAPPβ and CTFβ expressions, likely via the downregulation of BACE1 activities
*cognitive↑, In aged mice, lactoferrin treatment has been demonstrated to attenuate cognitive decline and hippocampal cell loss, as well as lower the markers of oxidative stress (e.g., reactive oxygen species; ROS and malondialdehyde; MDA
*MDA↓,
*IL6↓, and inflammation (e.g., interleukin 6; IL-6 and TNF-α) in the hippocampus.
*TNF-α↓,
*neuroP↑, ntioxidation and anti-inflammation to be involved in the neuroprotective effects of lactoferrin in APP/PS1 transgenic mouse model of AD.
*Dose↝, A pilot randomized controlled trial showed that lactoferrin capsules (250 mg/day of apo-Lf daily for three months) improved cognitive symptoms and biomarkers related to oxidative stres
*IronCh↑, Rousseau et al.71 also showed that the iron-binding capacity of lactoferrin could be neuroprotective but only in the context of iron-induced oxidative stress
*SOD↑, lactoferrin also exhibited antioxidative (reduced ROS levels and increased SOD expression)
*BioAv↝, Most in vivo studies involving AD and PD administered lactoferrin are conducted via intragastric gavage, intranasal instillation, or intraperitoneal injection


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   APOE4↓, 1,   Learn↑, 1,   PSEN1/PS1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

MDA↓, 1,   ROS↓, 1,   SOD↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Migration(tgid=13) ⓘ

cl‑APP↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Imm↑, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10↑, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 2,  
Total Targets: 24

Scientific Paper Hit Count for: APOE4, Apolipoprotein E ε4 Allele / ApoE4 Isoform
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1765  State#:%  Dir#:1
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