β-HEX Cancer Research Results

β-HEX, β-hexosaminidase Release: Click to Expand ⟱
Source:
Type:

β-Hexosaminidase Release

Abbreviation: β-HEX Release

Type: Mast-cell/basophil degranulation biomarker / functional outcome

Function: β-Hexosaminidase is a lysosomal enzyme stored in secretory granules of mast cells and basophils. Following activation, including IgE-FcεRI-mediated stimulation, β-hexosaminidase is released together with other granule mediators. Measurement of extracellular β-hexosaminidase activity is therefore widely used as a quantitative marker of mast-cell and basophil degranulation.

Asthma / Allergy: ↑ Increased β-hexosaminidase release indicates increased mast-cell or basophil degranulation and is associated with greater allergic mediator release. It is commonly used as an experimental endpoint for IgE-mediated allergic activation.

Favorable Direction in Asthma / Allergy: ↓ β-Hexosaminidase release is favorable and indicates reduced mast-cell/basophil degranulation and antiallergic activity.
Scientific Papers found: Click to Expand⟱
8154- lamb,    Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells
- in-vitro, Nor, NA
*IL6↓, lambertianic acid inhibited the production of interleukin-6 (IL-6), PGD(2) and LTC(4), the expression of COX-2 and the degranulation of β-hexosaminidase in the PMA plus calcimycin-induced BMMCs.
*PGD2↓,
*LTC4↓,
*COX2/PTGS2↓,
*β-HEX↓, figure5
*antiAll↑, Therefore, lambertianic acid was deemed to possess potentially anti-allergic activity.

8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, potential health benefits in attenuating obesity, allergies and different cancers including breast, liver, lung and prostate cancer.
*AntiCan↑,
*AMPK↑, rats with high fat diet (HFD)-induced obesity by activating adenosine monophosphate activated protein kinase (AMPK)
*β-HEX↓, it was also observed that LA can suppress the release of β-hexosaminidase in a concentration-independent manner in BMMC
NA↑, anti-allergic activity
TumCCA↑, LA-treated MDA-MB-231 cells revealed that LA induces G2/ M phase arrest
AMPK↑, , LA activates AMPK and acetyl-CoA carboxylase (ACC) through phosphorylation and can suppress protein kinase B (AKT) phosphorylation,
ACC↑,
p‑Akt↓,
FOXM1↓, LA actively attenuates the expression of forkhead box protein M1 (FOXM1) and its regulated gene products, including proliferative proteins (Cyclin B1) and anti-apoptotic proteins (X-linked inhibitor of apoptosis protein [XIAP] and B-cell lymphoma 2 [
CycB/CCNB1↓,
XIAP↓,
Bcl-2↓,
p‑STAT3↓, LA suppresses the phosphorylation of STAT3 and NF-κB, the expression of p300 and RelA/ p65 acetylation,
p‑NF-kB↓,
Bcl-xL↓, LA blocks the expression of NF-κB regulated genes, including anti-apoptotic proteins (Bcl-2, Bcl-xL, XIAP and survivin), angiogenic protein vascular endothelial growth factor (VEGF), inflammatory protein COX-2, oncogenic genes cellular myelocytomato
survivin↓,
VEGF↓,
COX2/PTGS2↓,
cMyc↓,
IL6↓, and inflammatory mediators IL-6 and tumour necrosis factor-alpha (TNF-α) in the MCF-7 cells
TNF-α↓,
ROS↑, LA exhibits anticancer effects on hepatocellular carcinoma cells (HCC) through induction of apoptotic pathway by ROS-dependent activation of liver kinase B1 (LKB1)/AMPK/ ACC signalling cascades
STK11/LKB1↑,
cl‑Casp3↑, it induces the cleavage of caspase-3 and PARP along with the suppression of antiapoptotic proteins, Bcl-2 and Bcl-xl.
cl‑PARP↑,
eff↑, LA (20 μM) together with TRAIL (20 ng/ml) shows significant cytocidal effects in TRAIL resistant nonsmall cell lung cancer cell
AR↓, LA exerts anticancer effects by suppressing AR pathway in AR-sensitive prostate cancer cells LNCaP.
TumCP↓, 24 h LA treatment downregulates cell proliferation by reducing several protein levels, including p-53, p-p53, p21, p27, cyclin D1 and cell division kinase 4 (CDK4).
p‑P53↓,
P21↓,
p27/CDKN1B↓,
cycD1/CCND1↓,
CDK4↓,
PSA↓, LA exhibits anticancer properties by inhibiting AR expression and PSA in cellular and secretory levels
STAT3↓, LA induces apoptosis via miRNA-134 mediated inhibition of STAT3 and RelA/p65 acetylation
ac‑p65↓,
*antiAll↑, In conclusion, LA could be utilized in treating allergies, obesity and different cancers.


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   AMPK↑, 1,   cMyc↓, 1,   STK11/LKB1↑, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   cl‑Casp3↑, 1,   p27/CDKN1B↓, 1,   survivin↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑P53↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXM1↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL6↓, 1,   p‑NF-kB↓, 1,   ac‑p65↓, 1,   PSA↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   FOXM1↓, 1,   IL6↓, 1,   PSA↓, 1,  
Total Targets: 37

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

antiAll↑, 2,   LTC4↓, 1,   β-HEX↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL6↓, 1,   PGD2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   Obesity↓, 1,  
Total Targets: 10

Scientific Paper Hit Count for: β-HEX, β-hexosaminidase Release
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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