ATF1 Cancer Research Results

ATF1, Activating Transcription Factor 1: Click to Expand ⟱
Source:
Type:

ATF1 - Activating Transcription Factor 1

Type: Transcription factor / CREB-ATF family member

Function: ATF1 is a transcription factor in the CREB/ATF family that binds cAMP-response elements and regulates genes involved in proliferation, survival, differentiation, metabolism, and cellular stress responses. Its transcriptional activity is controlled by phosphorylation and interactions with transcriptional cofactors.

Cancer: ↑ Frequently overexpressed or activated in multiple cancers and associated with increased proliferation, survival, migration, invasion, therapeutic resistance, and poor prognosis. ATF1 also participates directly in oncogenic gene fusions; the EWSR1-ATF1 fusion is a characteristic driver of clear cell sarcoma and occurs in several other rare tumors.
Scientific Papers found: Click to Expand⟱
8161- LapC,    Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells
- in-vitro, ESCC, KYSE-30 - in-vitro, ESCC, KYSE450 - in-vitro, ESCC, KYSE-510
RSK2/RPS6KA3/p90RSK2↓, Herein, we report that lapachol is a novel ribosomal protein S6 kinase 2 (RSK2) inhibitor that suppresses growth and induces intrinsic apoptosis in ESCC cells.
TumCG↓,
Apoptosis↑,
Casp3↑, We also found that lapachol induces mitochondria-mediated cellular apoptosis by activating caspases-3, -7, and PARP, inducing the expression of cytochrome c and BAX by inhibiting downstream molecules of RSK2.
Casp7↑,
PARP↑,
Cyt‑c↑,
BAX↑,
p‑CREB↓, Results indicated that the expression of the phosphorylated CREB, ATF1, and histone H3 proteins is dose‐dependently inhibited by lapachol treatment, whereas the level of the phosphorylated RSK protein is not changed
ATF1↓,
H3↓,
CycB/CCNB1↓, Results showed that lapachol reduces expression of phosphorylated histone H3 and the expression of cyclin B1, cyclin D3, cyclin D1, and phosphorylation of CDK2 (
cycD1/CCND1↓,
p‑CDK2↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ATF1↓, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑CREB↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Casp3↑, 1,   Casp7↑, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

p‑CDK2↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ATF1, Activating Transcription Factor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1769  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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