MMP14 Cancer Research Results
MMP14, MMP14: Click to Expand ⟱
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MMP-14, also known as membrane-type matrix metalloproteinase 14 (MT1-MMP), is an enzyme that plays a significant role in the degradation of extracellular matrix components.
Elevated levels of MMP-14 have been associated with poor prognosis in various cancers, including breast, colorectal, and lung cancers.
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Scientific Papers found: Click to Expand⟱
MMPs↓, potential therapeutic effects of cysteamine are likely due to the inhibition of matrix metalloproteinases (MMPs) in GBM.
MMP2↓, Cysteamine’s inhibition of MMP activity, especially the targeting of MMP2, MMP9, and MMP14, was observed at micromolar concentrations, suggesting the mechanism of action in suppressing invasion and cell migration is by inhibition of these MMPs.
MMP9↓,
MMP14↓,
TumCI↓,
TumCMig↓,
Dose↓, Concentrations of cysteamine less than 0.2 mM did not significantly decrease cell viability or tumor cell growth in GBM cell lines
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Migration ⓘ
MMP14↓, 1, MMP2↓, 1, MMP9↓, 1, MMPs↓, 1, TumCI↓, 1, TumCMig↓, 1,
Drug Metabolism & Resistance ⓘ
Dose↓, 1,
Total Targets: 7
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: MMP14, MMP14
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:200 State#:% Dir#:1
wNotes=on sortOrder:rid,rpid
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