miR-34a Cancer Research Results

miR-34a, mir-34 precursor family: Click to Expand ⟱
Source:
Type:
MiR-34a expression levels were correlated with tumor differentiation, lymphatic metastasis, clinical stages, and survival rates.

miR-34a is a well-known molecule transcriptionally induced by p53.

-Low miR-34a expression is common in cancers and is often associated with poor prognosis in various cancers, including breast, lung, colorectal, prostate, pancreatic, ovarian, and glioblastoma.
-High miR-34a expression is often associated with better prognosis and improved overall survival in various cancers.
Scientific Papers found: Click to Expand⟱
6300- Cro,    Interaction of saffron and its constituents with Nrf2 signaling pathway: A review
- Review, Nor, NA - Review, Arthritis, NA
*antiOx↑, many pharmacological properties such as anti-oxidant, anti-inflammatory, antitumor, antigenotoxic, anti-depressant, hepatoprotective, cardioprotective, and neuroprotective.
*Inflam↓,
*AntiTum↑,
*hepatoP↑,
*cardioP↑,
*neuroP↑,
*NRF2↑, review indicate that saffron and its constituents could induce the Nrf2 signaling pathway leading to its anti-oxidant and therapeutic effects.
*NF-kB↓, ↓Arthritic pain, inflammation, oxidative stress, NF-κB, iNOS, COX-2, IL-6, IL-10, IL-1β, and TNF-α ↑Nrf2 and HO-1
*iNOS↓,
*COX2↓,
*IL6↓,
*IL10↓,
*IL1β↓,
*TNF-α↓,
*HO-1↑,
ROS↑, ↑Cytotoxicity in cancer cells, ROS, oxidative stress, Nrf2, HO-1, NQO1, and NQO2 ↓LDHA, membrane potential, and ATP level in vitro/A549, HepG2, HCT-116, HeLa, and SK-OV-3 cancer cell lines
NQO1↑,
NRF2↑,
HO-1↑,
NQO2↑,
LDHA↓,
ATP↓,
*hepatoP↑, Hepatoprotective effects ↑SOD, CAT, GPx, and Nrf2 ↓ROS
*SOD↑,
*Catalase↑,
*GPx↑,
*NRF2↑,
*ROS↓,
*cardioP↑, ↓Cardioprotective, ER stress, GRP78, CHOP, apoptosis, and miR-34a ↑Nrf2, HO-1, and Sirt1
*ER Stress↓,
*GRP78/BiP↓,
*CHOP↓,
*Apoptosis↓,
*miR-34a↓,
*SIRT1↑,
chemoP↑, chemoprotective-protective effects of crocin is its anti-inflammatory and anti-oxidant functions


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

HO-1↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

LDHA↓, 1,  

Protein Folding & ER Stress ⓘ

NQO2↑, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   HO-1↑, 1,   NRF2↑, 2,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

SIRT1↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   iNOS↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

miR-34a↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   cardioP↑, 2,   hepatoP↑, 2,   neuroP↑, 1,  
Total Targets: 26

Scientific Paper Hit Count for: miR-34a, mir-34 precursor family
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:450  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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