PTP1B Cancer Research Results

PTP1B, protein tyrosine phosphatase 1B: Click to Expand ⟱
Source:
Type:
PTP1B (protein tyrosine phosphatase 1B) is a protein that has been linked to the development and progression of certain types of cancer. It plays a role in regulating insulin signaling, and dysregulation of this pathway can contribute to cancer cell growth and survival.
In cancer cells, PTP1B has been shown to promote processes such as epithelial-mesenchymal transition (EMT), which allows cancer cells to become more invasive and metastatic.
PTP1B inhibitors have been shown to reduce tumor growth and metastasis in various cancer models.
In general, PTP1B expression is upregulated in cancer cells, which can contribute to cancer progression and resistance to therapy.
Scientific Papers found: Click to Expand⟱
412- CUR,    Curcumin and Its New Derivatives: Correlation between Cytotoxicity against Breast Cancer Cell Lines, Degradation of PTP1B Phosphatase and ROS Generation
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
ROS↑, 25uM
PTP1B↓,

7891- IVT,  VT,    Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin
- NA, AD, NA
*AntiDiabetic↑, Vitexin and isovitexin, naturally occurring C-glycosylated derivatives of apigenin, have been known to possess potent anti-diabetic, anti-Alzheimer's disease (anti-AD), and anti-inflammatory activities.
*Inflam↓,
*AGEs↓, isovitexin was found as the most potent inhibitor against RLAR, HRAR, AGE, AChE, and BChE while vitexin showed the most potent PTP1B inhibitory activity.
*AChE↓,
*BChE↓,
*PTP1B↓,

8234- LCA,    Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment
- Review, AD, NA
*neuroP↑, Studies have reported the neuroprotective effects of Lico-A, suggesting its potential as a multitarget compound.
*PTP1B↓, Lico-A acts as a PTP1B inhibitor, enhancing cognitive activity through the BDNF-TrkB pathway and exhibiting inhibitory effects on microglia activation, which enables mitigation of neuroinflammation
*cognitive↑,
*BDNF↑,
*TrkB↝, It not only enhances cognitive activity via the BDNF-TrkB pathway
*cJun↓, Moreover, Lico-A inhibits c-Jun N-terminal kinase 1, a key enzyme involved in tau phosphorylation,
*p‑tau↓,
*AChE↓, Lico-A also acts as an acetylcholinesterase inhibitor, leading to increased levels of the neurotransmitter acetylcholine (Ach) in the brain.
*Ach↑,
*Aβ↓, Lico-A has shown the ability to reduce amyloid plaques, a hallmark of AD, and exhibits antioxidant properties by activating the nuclear factor erythroid 2-related factor 2 (Nrf2)
*antiOx↑,
*NRF2↑,
*AntiViral↑, figure 1
*Obesity↓,
*PI3K↑, The proposed mechanism is through the activation of the PI3K/Akt/mTOR
*Akt↑,
*mTOR↑,
*memory↑, Licochalcone A as an Acetylcholinesterase Inhibitor and Memory Enhancer
*BBB↑, Furthermore, its ability to penetrate the blood–brain barrier (BBB)


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Migration(tgid=13) ⓘ

PTP1B↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   NRF2↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   cJun↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↑, 1,   PI3K↑, 1,  

Migration(tgid=13) ⓘ

PTP1B↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF↑, 1,   p‑tau↓, 1,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,   Obesity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 23

Scientific Paper Hit Count for: PTP1B, protein tyrosine phosphatase 1B
1 Curcumin
1 Isovitexin
1 Vitexin
1 Licochalcone A
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:641  State#:%  Dir#:1
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