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| Salvia miltiorrhiza (Danshen; SM) — a traditional Chinese medicinal root containing two major bioactive classes: lipophilic tanshinones (e.g., tanshinone IIA, cryptotanshinone) and hydrophilic phenolic acids (e.g., salvianolic acid A/B). Studied in oncology, cardiovascular, and neurovascular contexts. Primary mechanisms (conceptual rank): Bioavailability / PK relevance: Tanshinones are lipophilic with poor oral bioavailability; phenolic acids more water-soluble but rapidly metabolized. Many in-vitro cancer effects occur at concentrations higher than typical plasma levels from oral preparations unless specialized formulations are used. In-vitro vs oral exposure: Anti-cancer cytotoxicity frequently at micromolar range (qualifier: high concentration only for direct tumor apoptosis). Clinical evidence status: Widely used in cardiovascular medicine (Asia); oncology evidence largely preclinical or adjunct-hypothesis; no major oncology RCT approval. Red sage, redroot sage, Chinese sage or danshen.Salvianolic Acid A (SAA) is predominantly isolated from Salvia miltiorrhiza, commonly known as Danshen. Tanshinone IIA is the main effective component of Salvia miltiorrhiza known as 'Danshen' Salvianolic Acid A, primarily derived from Salvia miltiorrhiza (Danshen), shows promise in cancer research due to its ability to inhibit cell proliferation, induce apoptosis, reduce angiogenesis, and impact multiple signaling pathways involved in tumor progression. Salvianolic Acid A may impact several intracellular signaling pathways involved in cancer progression: NF-κB Pathway: SAA might inhibit the NF-κB pathway, reducing inflammation and cell proliferation signals. MAPK Pathways (ERK, JNK, p38): By modulating these pathways, SAA can influence cell survival, differentiation, and apoptosis. PI3K/Akt Pathway: Inhibition of this pathway is another mechanism through which SAA can reduce cancer cell survival and proliferation. Oxidative Stress Reduction: SAA’s antioxidant properties may help in reducing oxidative stress, which is implicated in cancer progression and chemoresistance. Synergistic Effects with Conventional Therapies: Preliminary studies suggest that Salvianolic Acid A might enhance the effectiveness of various chemotherapeutic agents. Some studies have observed anti-proliferative effects at concentrations around 10–50 µM. rodent models have been reported in the range of 10–100 mg/kg Salvia miltiorrhiza (Danshen) — Cancer vs Normal Cell Pathway Map
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| TLR1 is one of the Toll-like receptors (TLRs), a family of pattern recognition receptors that play a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). TLR1 expression is not confined solely to immune cells; its expression has also been detected in various tumor cells as well as in the surrounding stroma. Aberrant expression or activation of TLR1 in the tumor microenvironment can influence both innate and adaptive immune responses within tumors. This modulation can have complex effects on tumor progression. Due to its dual role, TLR1 holds potential as both a prognostic biomarker and a therapeutic target. |
| 1195- | SM, | Salvia miltiorrhiza polysaccharide activates T Lymphocytes of cancer patients through activation of TLRs mediated -MAPK and -NF-κB signaling pathways |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Liver, | HepG2 | - | in-vitro, | CRC, | HCT116 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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