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| Salvia miltiorrhiza (Danshen; SM) — a traditional Chinese medicinal root containing two major bioactive classes: lipophilic tanshinones (e.g., tanshinone IIA, cryptotanshinone) and hydrophilic phenolic acids (e.g., salvianolic acid A/B). Studied in oncology, cardiovascular, and neurovascular contexts. Primary mechanisms (conceptual rank): Bioavailability / PK relevance: Tanshinones are lipophilic with poor oral bioavailability; phenolic acids more water-soluble but rapidly metabolized. Many in-vitro cancer effects occur at concentrations higher than typical plasma levels from oral preparations unless specialized formulations are used. In-vitro vs oral exposure: Anti-cancer cytotoxicity frequently at micromolar range (qualifier: high concentration only for direct tumor apoptosis). Clinical evidence status: Widely used in cardiovascular medicine (Asia); oncology evidence largely preclinical or adjunct-hypothesis; no major oncology RCT approval. Red sage, redroot sage, Chinese sage or danshen.Salvianolic Acid A (SAA) is predominantly isolated from Salvia miltiorrhiza, commonly known as Danshen. Tanshinone IIA is the main effective component of Salvia miltiorrhiza known as 'Danshen' Salvianolic Acid A, primarily derived from Salvia miltiorrhiza (Danshen), shows promise in cancer research due to its ability to inhibit cell proliferation, induce apoptosis, reduce angiogenesis, and impact multiple signaling pathways involved in tumor progression. Salvianolic Acid A may impact several intracellular signaling pathways involved in cancer progression: NF-κB Pathway: SAA might inhibit the NF-κB pathway, reducing inflammation and cell proliferation signals. MAPK Pathways (ERK, JNK, p38): By modulating these pathways, SAA can influence cell survival, differentiation, and apoptosis. PI3K/Akt Pathway: Inhibition of this pathway is another mechanism through which SAA can reduce cancer cell survival and proliferation. Oxidative Stress Reduction: SAA’s antioxidant properties may help in reducing oxidative stress, which is implicated in cancer progression and chemoresistance. Synergistic Effects with Conventional Therapies: Preliminary studies suggest that Salvianolic Acid A might enhance the effectiveness of various chemotherapeutic agents. Some studies have observed anti-proliferative effects at concentrations around 10–50 µM. rodent models have been reported in the range of 10–100 mg/kg Salvia miltiorrhiza (Danshen) — Cancer vs Normal Cell Pathway Map
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| A cytokine that regulates humoral and adaptive immunity, and is involved in allergies and regulates inflammation. IL-4 produced by cancer cells promotes resistance to immune checkpoint blockade (ICB). The close correlation between interleukin-4 (IL-4) and tumor progression has been observed in plenty of studies. IL-4 is expressed in various cancers, including breast cancer, lung cancer, colorectal cancer, and hematological malignancies. Its expression can vary depending on the tumor type and the immune context. Elevated levels of IL-4 are often associated with the presence of tumor-infiltrating immune cells, particularly Th2 cells and other immune cells that produce IL-4. IL-4 is often considered a pro-tumorigenic cytokine. It can promote tumor growth and survival by enhancing the proliferation and survival of cancer cells. IL-4 can activate signaling pathways such as the STAT6 pathway, which is associated with cell proliferation and survival. In some cancers, IL-4 can also promote angiogenesis, the formation of new blood vessels, which is critical for tumor growth and metastasis. |
| 1195- | SM, | Salvia miltiorrhiza polysaccharide activates T Lymphocytes of cancer patients through activation of TLRs mediated -MAPK and -NF-κB signaling pathways |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Liver, | HepG2 | - | in-vitro, | CRC, | HCT116 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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