Thymol-Thymus vulgaris / OCLN Cancer Research Results

TV, Thymol-Thymus vulgaris: Click to Expand ⟱
Features:
Thyme
-
OCLN, Occludin: Click to Expand ⟱
Source:
Type:
Occludin 
Target/Pathway: Occludin
Abbreviation: OCLN
Category: Tight junction / intestinal barrier
Direction in IBD: usually down
Cancer relevance: usually barrier-loss associated, especially in inflammation-linked colorectal cancer


Scientific Papers found: Click to Expand⟱
5934- TV,    Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological Properties
- Review, Var, NA
*Inflam↓, *antiOx↑, *Bacteria↓, AntiTum↑, *toxicity∅, *IBI↑, *ZO-1↑, *OCLN↑, *COX1↑, *TLR4↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *TAC↑, *NRF2↑, *GutMicro↑,
5935- TV,  CAR,    Effects of thymol and carvacrol supplementation on intestinal integrity and immune responses of broiler chickens challenged with Clostridium perfringens
- in-vivo, Nor, NA
*Dose↝, *OCLN↑, *TLR2↓, *TNF-α↓, Bacteria↓, GutMicro↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   NRF2↑, 1,   TAC↑, 1,  

Migration ⓘ

ZO-1↑, 1,  

Barriers & Transport ⓘ

IBI↑, 1,   OCLN↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX1↑, 1,   IL1β↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 2,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 17

Scientific Paper Hit Count for: OCLN, Occludin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:161  Target#:1463  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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