Vitamin K2 / SXR Cancer Research Results

VitK2, Vitamin K2: Click to Expand ⟱
Features:
Vitamin K2 (menaquinone)
Menaquinone-4 (MK-4), a subtype of vitamin K2 Helps blood clot, calcium metabolise and heart health.
Bone health: Vitamin K2 helps to regulate calcium levels in the body, which can help to prevent conditions such as osteoporosis and fractures.
Vitamin K2 has been studied for its potential role in cancer prevention and treatment. Some of the key findings include:
-Shown to inhibit the growth of cancer cells, including those found in leukemia, lung cancer, and prostate cancer.
-Shown to induce apoptosis (cell death) in cancer cells, which can help to prevent the spread of cancer.
-Shown to have anti-angiogenic effects, which means it can help to prevent the formation of new blood vessels that feed cancer cells.
-Synergistic effects with other nutrients, such as vitamin D and calcium, to enhance its anti-cancer effects.

UBIAD1 is the enzyme that makes MK-4 inside tissues

Vitamin K2 exists in several forms known as menaquinones, with MK-4 and MK-7 being the most studied. MK-4 is often used in Japan for therapeutic purposes, whereas MK-7 (derived from bacterial fermentation) is widely available as a supplement in Western countries.
For bone and cardiovascular health—and by extension, exploring potential anticancer benefits—doses for MK-7 commonly range from 90 to 200 micrograms per day.
SXR, PXR-Steroid and Xenobiotic Receptor: Click to Expand ⟱
Source:
Type:
SXR (Steroid and Xenobiotic Receptor, also known as Pregnane X Receptor, PXR).
-SXR/PXR is a nuclear receptor that is primarily known for its role in detecting and mediating the metabolism and clearance of xenobiotics, drugs, and endogenous compounds.

- Since SXR/PXR regulates drug-metabolizing enzymes and transporters, overexpression in tumor cells may lead to increased metabolism and clearance of anticancer drugs, potentially contributing to chemoresistance.

– Some studies suggest that high SXR/PXR expression might be linked to more aggressive tumor behavior in certain cancers, such as breast, prostate, and gastrointestinal cancers, as it can alter cellular metabolic states and modulate survival pathways.
Scientific Papers found: Click to Expand⟱
2285- VitK2,    New insights into vitamin K biology with relevance to cancer
- Review, Var, NA
Risk↓, AntiCan↑, eff↑, MMP↓, ROS↑, Cyt‑c↑, eff↓, SXR↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Cyt‑c↑, 1,  

Hormonal & Nuclear Receptors ⓘ

SXR↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,   eff↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   Risk↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SXR, PXR-Steroid and Xenobiotic Receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:168  Target#:1283  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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