Radiotherapy/Radiation / PGC1A Cancer Research Results

Rad, Radiotherapy/Radiation: Click to Expand ⟱
Features:
Treatment of disease with radiation, especially by selective irradiation with x-rays or other ionizing radiation and by ingestion of radioisotopes.

Radiosensitizer
Atorvaqone, (mitochondria inhibitor) decrease O2 consumption making more O2 available as a radiosensitizer.
PGC1A, PPARγ Coactivator 1-alpha: Click to Expand ⟱
Source:
Type:
PPARγ Coactivator 1-alpha (PGC1A) is a transcriptional coactivator that plays a crucial role in regulating cellular energy metabolism, including glucose and lipid metabolism. In cancer, PGC1A has been implicated in the regulation of tumor cell metabolism, proliferation, and survival.

PGC1A is typically overexpressed and associated with poor prognosis and reduced overall survival in breast, lung, and colon cancers.
-PGC1A expression is also associated with increased risk of metastasis and recurrence in various types of cancer.
Scientific Papers found: Click to Expand⟱
3012- RosA,  Rad,    Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROSMYPT1TGFβ1 Signaling Via miR-19b-3p
- in-vitro, Nor, IMR90
*Inflam↓, *ROS↓, *p‑NF-kB↓, *Rho↓, *ROCK1↓, *radioP↑, *MCP1↓, *RANTES↓, *ICAM-1↓, *PGC1A↑, *NOX4↓, *Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

NOX4↓, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

PGC1A↑, 1,  

Migration ⓘ

Rho↓, 1,   ROCK1↓, 1,  

Immune & Inflammatory Signaling ⓘ

ICAM-1↓, 1,   Inflam↓, 1,   MCP1↓, 1,   p‑NF-kB↓, 1,   RANTES↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

radioP↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: PGC1A, PPARγ Coactivator 1-alpha
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:201  Target#:955  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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