| Features: |
| Wortmannin is a naturally occurring compound that is known for its inhibitory effects on certain enzymes, particularly phosphatidylinositol 3-kinase (PI3K). It is a fungal metabolite that was first isolated from the fungus Penicillium wortmanni. Widely used in research as a tool to study the PI3K signaling pathway. -known as AKT inhibitor Wortmannin is a potent, naturally derived compound best known for its role as an inhibitor of phosphoinositide 3-kinases (PI3Ks). Unlike vitamins such as vitamin D or vitamin K2, wortmannin is not used as a nutritional supplement or therapeutic agent in the typical clinical setting. - In cell culture studies, wortmannin is commonly used at concentrations in the low nanomolar range (e.g., 10–100 nM) to inhibit PI3K activity. - In animal models, the dosing regimen can vary widely depending on the species, route of administration, and study design. Typical experimental doses may range from 0.1 to 1.0 mg/kg, but these studies are primarily investigative and not directed toward therapeutic dosing in humans. |
| Source: |
| Type: |
| -Promoting cell survival: Autophagosome accumulation can provide cancer cells with a means to survive under stressful conditions, such as nutrient deprivation or hypoxia. -Inducing cell death: Autophagosome accumulation can lead to cell death in certain contexts, such as in response to chemotherapy or radiation therapy. Molecular Mechanisms: mTOR Pathway: The mechanistic target of rapamycin (mTOR) is a key regulator of autophagy. Inhibition of mTOR can lead to increased autophagosome formation. Beclin-1: This protein is essential for the initiation of autophagy and is often downregulated in various cancers, affecting autophagosome formation. LC3 Protein: The conversion of LC3-I to LC3-II is a marker of autophagosome formation and is often studied in cancer research. Generally, high levels of autophagosome accumulation and autophagy-related protein expression are associated with poor prognosis in many cancers, particularly in advanced stages or in the context of treatment resistance. |
| 312- | AgNPs, | wortm, | Inhibition of autophagy enhances the anticancer activity of silver nanoparticles |
| - | vitro+vivo, | Cerv, | HeLa |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:202 Target#:613 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid