methotrexate / RenoP Cancer Research Results

MTX, methotrexate: Click to Expand ⟱
Features:
Methotrexate is a chemotherapy medication that has been used to treat various types of cancer.
Methotrexate works by:
Inhibiting dihydrofolate reductase (DHFR): Methotrexate binds to DHFR, an enzyme that is necessary for the production of tetrahydrofolate, a co-factor for DNA synthesis.
Interfering with DNA synthesis: By inhibiting DHFR, methotrexate prevents the production of tetrahydrofolate, which is necessary for DNA synthesis.
Inducing apoptosis: Methotrexate can induce apoptosis (programmed cell death) in cancer cells.
RenoP, K,Renoprotection: Click to Expand ⟱
Source:
Type:
Protects kidneys
-Same as nephroprotective
Opposite is : Nephrotoxicity is toxicity in the kidneys
Scientific Papers found: Click to Expand⟱
2111- TQ,  MTX,    Effect of Nigella sativa (black seeds) against methotrexate-induced nephrotoxicity in mice
- in-vivo, Nor, NA
*RenoP↑, *GSH↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,  

Functional Outcomes ⓘ

RenoP↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: RenoP, K,Renoprotection
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:223  Target#:1175  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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