temozolomide / LC3B-II Cancer Research Results

TMZ, temozolomide: Click to Expand ⟱

Features:

Temozolomide is a chemotherapeutic agent used to treat: GBM
Temozolomide works by interfering with DNA replication: temozolomide is a alkylating agent that adds an alkyl group to the DNA molecule, which interferes with the replication of DNA and ultimately leads to cell death.

LC3B-II, LC3B-II: Click to Expand ⟱

Source:

Type:

LC3B-II is a lipidated form of LC3B that is widely used as a marker for autophagy.

-Several studies have reported that higher levels of LC3B-II correlate with more aggressive tumor behavior.
-Prognostic Implication: Increased LC3B-II expression is often associated with poorer prognosis, including reduced overall survival and disease‐free survival. This may reflect a role for autophagy in tumor cell survival under stress.

-Dual Role of Autophagy: Autophagy (and therefore LC3B-II expression) may act as both a tumor suppressor and a tumor promoter depending on the tumor type, stage, and microenvironment.

Scientific Papers found: Click to Expand⟱

1912-

HCQ,

TMZ,

Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy

in-vivo,

GBM,

U87MG

mice

LC3B-II↑, CHOP↑, cl‑PARP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Protein Folding & ER Stress ⓘ

CHOP↑, 1,

Autophagy & Lysosomes ⓘ

LC3B-II↑, 1,

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: LC3B-II, LC3B-II

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells