PXD, phenoxodiol / aSmase Cancer Research Results

Phen, PXD, phenoxodiol: Click to Expand ⟱
Features:
Phenoxodiol (PXD) is a synthetic compound that has been investigated as a potential therapeutic agent for the treatment of various types of cancer.
Phenoxodiol is an inhibitor of ENOX2 (ecto-nicotinamide adenine dinucleotide oxidase 2), also known as tNOX (tumor-associated NADH oxidase).
aSmase, Acid Sphingomyelinase: Click to Expand ⟱
Source:
Type:
A-SMase expression correlates inversely with tumour stage in human melanoma biopsies.In melanoma, expression of acid sphingomyelinase decreases with tumor progression in both humans and mice. A-SMase expression correlates inversely with tumour stage in human melanoma biopsies.

The SMase family includes different isoenzymes mainly distinguished by their optimal pH:
-Acid sphingomyelinase (aSMase):Encoded by the gene SMPD1.Functions optimally at acidic pH.
-Neutral sphingomyelinases (nSMases):(nSMase1, nSMase2, nSMase3) encoded by genes SMPD2, SMPD3.
-Alkaline sphingomyelinases: typically found in the intestinal tract.

aSMase expression or activity is reduced compared to normal tissue. Lower aSMase activity can lead to decreased ceramide generation, potentially allowing cancer cells to avoid apoptosis.

In many cancer-related studies where the term “SMase” is used without further specification, the discussion may center on aSMase because of its link to ceramide production and apoptosis under stress conditions (such as chemotherapy or radiotherapy).
Scientific Papers found: Click to Expand⟱
1515- EGCG,  Phen,    Reciprocal Relationship Between Cytosolic NADH and ENOX2 Inhibition Triggers Sphingolipid-Induced Apoptosis in HeLa Cells
- in-vitro, Cerv, HeLa - in-vitro, Nor, MCF10 - in-vitro, BC, BT20
selectivity↑, ENOX2↓, NADH↑, SK↓, eff↑, aSmase↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ENOX2↓, 1,   NADH↑, 1,  

Cell Death ⓘ

aSmase↑, 1,   SK↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: aSmase, Acid Sphingomyelinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:237  Target#:394  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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