erastin / ChemoSen Cancer Research Results

erastin, erastin: Click to Expand ⟱

Features:

Erastin is often referred to as a "metabolic inhibitor" or a "ferroptosis inducer", rather than a traditional chemotherapy agent.
Erastin is primarily available as a research chemical—it's not an approved therapeutic for clinical use.

Pathways:
-Erastin inhibits system xCT, thereby reducing cystine uptake. This leads to decreased intracellular cysteine, a precursor for GSH. As a consequence, the cell’s glutathione levels drop, compromising its ability to neutralize reactive oxygen species (ROS).
-Glutathione (GSH) Depletion and Increased Oxidative Stress
-Voltage-Dependent Anion Channels (VDACs): Altering VDAC function can affect mitochondrial metabolism, leading to changes in energy production and further enhancing oxidative stress.

ChemoSen, chemo-sensitization: Click to Expand ⟱

Source:

Type:

The effectiveness of chemotherapy by increasing cancer cell sensitivity to the drugs used to treat them, which is known as “chemo-sensitization”.

Chemo-Sensitizers:
-Curcumin
-Resveratrol
-EGCG
-Quercetin
-Genistein
-Berberine
-Piperine: alkaloid from black pepper
-Ginsenosides: active components of ginseng
-Silymarin
-Allicin
-Lycopene
-Ellagic acid
-caffeic acid phenethyl ester
-flavopiridol
-oleandrin
-ursolic acid
-butein
-betulinic acid

Scientific Papers found: Click to Expand⟱

727-

Bor,

RSL3,

erastin,

Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy

in-vitro,

Liver,

HepG2

ROS↑, GSH↓, TBARS↑, Ferroptosis↑, ChemoSen↑,

5047-

erastin,

The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells

in-vitro,

Ovarian,

xCT↓, GSH↓, Ferroptosis↑, ChemoSen↑, eff↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Ferroptosis↑, 2, GSH↓, 2, ROS↑, 1, TBARS↑, 1, xCT↓, 1,

Cell Death ⓘ

Ferroptosis↑, 2,

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2, eff↑, 1,
Total Targets: 8

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: ChemoSen, chemo-sensitization

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells