Ras-selective lethal 3 / ChemoSen Cancer Research Results

RSL3, Ras-selective lethal 3: Click to Expand ⟱

Features: ferroptosis inducer

RSL3 (Ras-selective lethal 3) is a small molecule that has been shown to have anti-cancer properties. It is a ferroptosis inducer, which means that it induces a type of cell death that is characterized by the accumulation of iron and the production of reactive oxygen species (ROS).

RSL3 works by inhibiting the activity of the enzyme GPX4 (glutathione peroxidase 4), which is involved in the regulation of lipid peroxidation and the maintenance of cellular redox balance. In cancer cells, GPX4 is often overexpressed, and RSL3's inhibition of this enzyme leads to an accumulation of lipid peroxides and a disruption in cellular redox balance.

ChemoSen, chemo-sensitization: Click to Expand ⟱

Source:

Type:

The effectiveness of chemotherapy by increasing cancer cell sensitivity to the drugs used to treat them, which is known as “chemo-sensitization”.

Chemo-Sensitizers:
-Curcumin
-Resveratrol
-EGCG
-Quercetin
-Genistein
-Berberine
-Piperine: alkaloid from black pepper
-Ginsenosides: active components of ginseng
-Silymarin
-Allicin
-Lycopene
-Ellagic acid
-caffeic acid phenethyl ester
-flavopiridol
-oleandrin
-ursolic acid
-butein
-betulinic acid

Scientific Papers found: Click to Expand⟱

727-

Bor,

RSL3,

erastin,

Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy

in-vitro,

Liver,

HepG2

ROS↑, GSH↓, TBARS↑, Ferroptosis↑, ChemoSen↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1, GSH↓, 1, ROS↑, 1, TBARS↑, 1,

Cell Death ⓘ

Ferroptosis↑, 1,

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: ChemoSen, chemo-sensitization

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells