Ras-selective lethal 3 / Ferroptosis Cancer Research Results

RSL3, Ras-selective lethal 3: Click to Expand ⟱

Features: ferroptosis inducer

RSL3 (Ras-selective lethal 3) is a small molecule that has been shown to have anti-cancer properties. It is a ferroptosis inducer, which means that it induces a type of cell death that is characterized by the accumulation of iron and the production of reactive oxygen species (ROS).

RSL3 works by inhibiting the activity of the enzyme GPX4 (glutathione peroxidase 4), which is involved in the regulation of lipid peroxidation and the maintenance of cellular redox balance. In cancer cells, GPX4 is often overexpressed, and RSL3's inhibition of this enzyme leads to an accumulation of lipid peroxides and a disruption in cellular redox balance.

Ferroptosis, Ferroptosis: Click to Expand ⟱

Source:

Type: type of cell death

Type of programmed cell death dependent on iron.
Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides to lethal levels. It is distinct from other forms of cell death, such as apoptosis, necrosis, and autophagy. The process of ferroptosis is heavily dependent on iron metabolism and reactive oxygen species (ROS).
The accumulation of lipid peroxides is a hallmark of ferroptosis. This can occur when the antioxidant defenses, such as glutathione and selenoproteins, are overwhelmed or inhibited. Many cancer cells upregulate GPX4 to evade ferroptosis, making it a potential target for therapy. It has been described that GPX4, xCT and ACSL-4 are the main targets in the regulation of ferroptosis.

Scientific Papers found: Click to Expand⟱

727-

Bor,

RSL3,

erastin,

Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy

in-vitro,

Liver,

HepG2

ROS↑, GSH↓, TBARS↑, Ferroptosis↑, ChemoSen↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1, GSH↓, 1, ROS↑, 1, TBARS↑, 1,

Cell Death ⓘ

Ferroptosis↑, 1,

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Ferroptosis, Ferroptosis

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells