| Features: |
| Probiotics contain live bacteria the supplements the gastrointestinal flora. (Which can be affected from infection or antibiotics drugs.) Some studies have suggested that gut microbiota—including Bifidobacterium species—can affect systemic immunity. This is important because the state of the immune system influences the body’s ability to fight cancer and also the response to immunotherapies. Preclinical investigations have demonstrated that certain Bifidobacterium strains may help improve responses to immune checkpoint inhibitors in animal models. There has been emerging research looking into discrete strains or formulations of Bifidobacterium longum (sometimes labeled with additional identifiers such as RAPO) that may have unique properties or enhanced effects. |
| Source: |
| Type: |
| Intestinal Barrier Integrity (IBI) refers to the functional integrity of the gut mucosal barrier, including epithelial tight junctions, mucus protection, antimicrobial defenses, and control of luminal antigen and microbial translocation. Loss of intestinal barrier integrity increases permeability, promotes endotoxin and cytokine-driven inflammation, and can sustain tumor-supportive signaling through NF-κB, STAT3, oxidative stress, and immune dysregulation. In IBD, barrier disruption is a core pathogenic feature that amplifies chronic mucosal inflammation and tissue injury. In cancer, especially colorectal cancer, persistent barrier dysfunction may contribute to initiation, progression, and a pro-inflammatory microenvironment, although in some treatment contexts increased permeability can also alter drug exposure or immune interactions. Agents that improve intestinal barrier integrity may be relevant in IBD-associated carcinogenesis and in reducing inflammation-linked tumor promotion. Related terms/synonyms: gut barrier, epithelial barrier, mucosal barrier, intestinal permeability, leaky gut. |
| - | Trial, | CRC, | NA |
| 8122- | LA, | ProBio, | Probiotics in colorectal cancer: mechanisms, biomarkers, and adjunct strategies |
| - | Review, | CRC, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:256 Target#:1462 State#:% Dir#:2
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