Selenate / FADD Cancer Research Results

Selenate, Selenate: Click to Expand ⟱

Features:

Selenate shares similarity with sulfate and enters cells via sulfate transporters; however, it is less readily reduced and often considered less potent in rapid cytotoxicity effects.

Selenate tends to exhibit higher IC50 values (often in the 10–100 µM range), indicating reduced potency compared to selenite in directly inducing cancer cell death.

Less Direct ROS Generation than Selenite.
– Selenate’s toxicity is generally less acute because it is a more inert species until metabolically reduced.
– It may exert its anticancer effects once it is converted into reduced selenium species that eventually can contribute to ROS production.

FADD, FADD: Click to Expand ⟱

Source:

Type:

FADD (Fas-associated protein with death domain) is a protein that plays a crucial role in the apoptotic signaling pathway, particularly in the process of programmed cell death. It is involved in the signaling of death receptors, such as Fas (CD95), which, when activated, can lead to apoptosis in cells.
FADD has a dual role. On one hand, it can promote apoptosis in response to certain signals, which is a mechanism that can prevent the proliferation of cancer cells. On the other hand, some cancer cells may exploit the apoptotic pathways to evade cell death, leading to tumor survival and growth.

Expression: FADD is often expressed in breast cancer cells, and its levels can vary among different subtypes.
Prognosis: High levels of FADD expression have been associated with increased apoptosis in response to certain therapies, which may correlate with better treatment outcomes. However, in some contexts, FADD can also promote cell survival, complicating its role in prognosis.

Scientific Papers found: Click to Expand⟱

4493-

Chit,

Selenate,

Se,

A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway

in-vitro,

Lung,

A549

tumCV↓, Apoptosis↑, TumCCA↑, Fas↑, FasL↑, FADD↑, Casp↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis↑, 1, Casp↑, 1, FADD↑, 1, Fas↑, 1, FasL↑, 1,

Transcription & Epigenetics ⓘ

tumCV↓, 1,

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: FADD, FADD

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells