Selenate / Vim Cancer Research Results

Selenate, Selenate: Click to Expand ⟱

Features:

Selenate shares similarity with sulfate and enters cells via sulfate transporters; however, it is less readily reduced and often considered less potent in rapid cytotoxicity effects.

Selenate tends to exhibit higher IC50 values (often in the 10–100 µM range), indicating reduced potency compared to selenite in directly inducing cancer cell death.

Less Direct ROS Generation than Selenite.
– Selenate’s toxicity is generally less acute because it is a more inert species until metabolically reduced.
– It may exert its anticancer effects once it is converted into reduced selenium species that eventually can contribute to ROS production.

Vim, Vimentin: Click to Expand ⟱

Source:

Type:

Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously expressed in normal mesenchymal cells and is known to maintain cellular integrity and provide resistance against stress. Vimentin is overexpressed in various epithelial cancers, including prostate cancer, gastrointestinal tumors, tumors of the central nervous system, breast cancer, malignant melanoma, and lung cancer. Vimentin’s overexpression in cancer correlates well with accelerated tumor growth, invasion, and poor prognosis; however, the role of vimentin in cancer progression remains obscure.

In many epithelial-derived tumors (carcinomas), elevated Vimentin expression is often observed in cancer cells that have undergone EMT. This upregulation is characteristic of a shift toward a mesenchymal state, which is associated with reduced cell–cell adhesion and increased motility. Vimentin expression is also noted in the tumor stroma, reflecting the presence and activation of mesenchymal cells such as cancer-associated fibroblasts (CAFs). This dual expression can contribute to the remodeling of the tumor microenvironment.
The degree of Vimentin expression may vary depending on the tumor type, grade, and stage. More aggressive and advanced tumors tend to show higher levels of Vimentin expression.

High Vimentin expression has been correlated with poor clinical outcomes in several cancers, including breast, colorectal, prostate, and lung cancers.
Elevated Vimentin levels are typically associated with higher tumor grade, increased invasiveness, enhanced metastatic potential, and a greater risk of recurrence.
As a component of the EMT signature, high Vimentin expression can serve as an indicator of a more aggressive tumor phenotype and is often associated with reduced overall survival.
- vimentin up-regulation is often used as a marker of EMT in cancer

Scientific Papers found: Click to Expand⟱

1135-

Selenate,

Selenate induces epithelial-mesenchymal transition in a colorectal carcinoma cell line by AKT activation

in-vitro,

CRC,

DLD1

880uM

EMT↑, Akt↑, Twist↑, Vim↑, E-cadherin↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Akt↑, 1,

Proliferation, Differentiation & Cell State ⓘ

EMT↑, 1,

Migration ⓘ

E-cadherin↓, 1, Twist↑, 1, Vim↑, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Vim, Vimentin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells