Selenate / FasL Cancer Research Results

Selenate, Selenate: Click to Expand ⟱

Features:

Selenate shares similarity with sulfate and enters cells via sulfate transporters; however, it is less readily reduced and often considered less potent in rapid cytotoxicity effects.

Selenate tends to exhibit higher IC50 values (often in the 10–100 µM range), indicating reduced potency compared to selenite in directly inducing cancer cell death.

Less Direct ROS Generation than Selenite.
– Selenate’s toxicity is generally less acute because it is a more inert species until metabolically reduced.
– It may exert its anticancer effects once it is converted into reduced selenium species that eventually can contribute to ROS production.

FasL, Fas ligand: Click to Expand ⟱

Source:

Type:

Fas ligand (FasL) is a protein that plays a crucial role in the regulation of the immune system and programmed cell death, also known as apoptosis. In the context of cancer, FasL has been found to have both tumor-promoting and tumor-suppressing effects.
FasL is upregulated in melanoma, colon.
FasL: tumor suppressing effect on Breast and Lung cancer.

FasL inhibitors, which block the interaction between Fas and FasL, have been shown to enhance the effectiveness of chemotherapy and immunotherapy

Scientific Papers found: Click to Expand⟱

4493-

Chit,

Selenate,

Se,

A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway

in-vitro,

Lung,

A549

tumCV↓, Apoptosis↑, TumCCA↑, Fas↑, FasL↑, FADD↑, Casp↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis↑, 1, Casp↑, 1, FADD↑, 1, Fas↑, 1, FasL↑, 1,

Transcription & Epigenetics ⓘ

tumCV↓, 1,

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: FasL, Fas ligand

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells