verapamil / Casp Cancer Research Results

Vem, verapamil: Click to Expand ⟱
Features:
Verapamil belongs to the phenylalkylamine class of compounds and is a fully synthetic molecule originally developed for its potent calcium channel–blocking properties.

Pathways:
-P-glycoprotein Inhibition (MDR1). -P-gp is overexpressed in many cancer cells
-Inhibition of P-gp by verapamil can enhance the intracellular concentration of chemotherapeutic agents, potentially restoring drug sensitivity.
-As a calcium channel blocker, verapamil inhibits L-type calcium channels.
Casp, caspase: Click to Expand ⟱
Source:
Type:
The caspase family of proteases are essential to initiate and execute apoptotic cell death. Targeting caspase pathways by gene therapy or endogenous inhibitors represents a promising therapeutic strategy for cancer.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Scientific Papers found: Click to Expand⟱
1960- GamB,  Vem,    Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation
- in-vitro, Liver, HepG2 - in-vitro, AML, K562
Proteasome↓, eff↑, Casp↑, ER Stress↑, ROS↑, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Casp↑, 1,   Proteasome↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 2,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Casp, caspase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:303  Target#:443  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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