triptolide / GSDME-N Cancer Research Results

Trip, triptolide: Click to Expand ⟱
Features:
Triptolide is a diterpenoid triepoxide primarily isolated from the traditional Chinese medicinal plant Tripterygium wilfordii Hook F (commonly known as Thunder God Vine).

Pathways:
-Activation of caspases (key executioners of apoptosis)
-Disruption of mitochondrial membrane potential
-Cell Cycle Arrest
-Suppresses expression of c-myc and mitochondrial hexokinase II (HK-II) in cancer cells
GSDME-N, N‐terminal domain of Gasdermin E: Click to Expand ⟱
Source:
Type:
GSDME‐N fragment (the N‐terminal domain of Gasdermin E)
• GSDME (Gasdermin E) is a member of the gasdermin family and is cleaved by caspase‐3 during apoptosis. This cleavage releases the N‐terminal fragment (GSDME‐N), which can form pores in the cell membrane, inducing pyroptosis—a proinflammatory form of programmed cell death.

• Some studies have found that high levels of GSDME expression, which can lead to increased GSDME‐N formation upon cleavage, correlate with enhanced pyroptosis in tumor cells.
• In select breast cancer cohorts, increased pyroptosis may contribute to a more robust local immune response, potentially correlating with improved prognosis.

- Formation of the GSDME‐N fragment and its associated induction of pyroptosis might, in some contexts, favor a more robust anti‐tumor immune response and potentially better clinical outcomes.
Scientific Papers found: Click to Expand⟱
2454- Trip,    Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
- in-vitro, HNSCC, HaCaT - in-vivo, NA, NA
GSDME-N↑, Pyro↑, cMyc↓, HK2↓, BAD↑, BAX↑, Casp3↑, NRF2↓, xCT↓, ROS↑, eff↑, Glycolysis↓, GlucoseCon↓, lactateProd↓, ATP↓, xCT↓, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NRF2↓, 1,   ROS↑, 1,   xCT↓, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,  

Cell Death ⓘ

BAD↑, 1,   BAX↑, 1,   Casp3↑, 1,   GSDME-N↑, 1,   Pyro↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 2,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GSDME-N, N‐terminal domain of Gasdermin E
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:324  Target#:1216  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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