S-adenosyl-L-methionine / 5HT Cancer Research Results

SAMe, S-adenosyl-L-methionine: Click to Expand ⟱
Features:
S-adenosyl-L-methionine (SAMe) is a naturally occurring compound involved in methylation, transsulfuration, and aminopropylation pathways. It has been studied for its potential therapeutic effects in various diseases, including cancer and Alzheimer’s disease (AD).
- B-12 and folic acid to help facilitate the effects of SAMe

-In AD, hypomethylation of certain genes (e.g. APP, BACE1) leads to increased amyloid-β production. SAMe supplementation may reverse this.
-SAMe is a cofactor in the synthesis of dopamine, serotonin, and norepinephrine, which are often deficient in AD and depression.
-Studies in AD animal models show improved cognitive function, reduced amyloid plaque formation, and restored methylation patterns
-Some human data support cognitive improvement when combined with B vitamins and folate, especially in early or mild cognitive impairment.

Cancer:
-Tumor suppessive in some cancers, pro-tumor risks in others.
5HT, Serotonin: Click to Expand ⟱
Source:
Type:
Serotonin (5-hydroxytryptamine or 5-HT) is best known as a neurotransmitter; however, it also plays diverse roles in peripheral tissues, including modulation of cell proliferation, angiogenesis, and immune responses.

Several studies have identified the expression of multiple 5-HT receptors (e.g., 5-HT1A, 5-HT2A, and 5-HT7) in breast cancer cells.
Serotonin may promote tumor cell proliferation and can influence breast cancer progression through receptor-mediated signaling pathways.

Expression of 5-HT and its receptors is documented in various cancers including breast, colorectal, pancreatic, prostate, and hepatocellular carcinoma.
Overexpression of particular 5-HT receptors often correlates with increased cell proliferation, angiogenesis, and metastatic potential.
High levels of 5-HT receptor expression generally serve as a marker for poor prognosis, although the exact prognostic implications vary depending on the specific receptor subtype and tumor type.

-Vomiting caused by chemotherapy was thought to result from the fact that the chemotherapeutics stimulated the secretion of 5-HT in intestinal chromaffin cells, and then 5-HT acted on 5-HT receptor which caused excitation of nerves and vomiting reflex.
Scientific Papers found: Click to Expand⟱
4114- SAMe,    S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research
- Review, AD, NA
*Mood↑, *BBB↑, *5HT↑, *p‑tau↓, *Aβ↓, *other↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics ⓘ

other↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Functional Outcomes ⓘ

Mood↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: 5HT, Serotonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:352  Target#:1119  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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