Cysteamine / ARE Cancer Research Results

Cyste, Cysteamine: Click to Expand ⟱

Features:

Cysteamine is a prescription drug, approved for treating cystinosis
-it is not sold over-the-counter as a dietary supplement.
-In contrast, related compounds like N-acetylcysteine (NAC) and pantethine are widely available supplements and can indirectly support cysteamine-related pathways (e.g., antioxidant defenses and CoA metabolism).

-Pantethine: Precursor to CoA, which breaks down into cysteamine
-Pantothenic Acid (Vitamin B5): Required for CoA synthesis

-Cysteamine increases glutathione (GSH) levels, reducing oxidative stress, a major contributor to AD pathology.
-Some studies suggest that cysteamine increases brain-derived neurotrophic factor (BDNF) levels
-Cysteamine has been observed to reduce amyloid plaque burden in animal models of AD.

ARE, antioxidant responsive element (ARE): Click to Expand ⟱

Source:

Type:

antioxidant responsive element (ARE)
ARE in Normal Cells: Protective Role
ARE-regulated genes include NQO1, HO-1, GCLM, GCLC, and various glutathione S-transferases (GSTs).
-Detoxify reactive oxygen species (ROS)
-Agents like sulforaphane (from broccoli) can activate ARE in healthy cells to prevent cancer initiation.
-overactivation in cancer cells aids cancer survival, growth, resistance

Scientific Papers found: Click to Expand⟱

4333-

Cyste,

Cystamine protects from 3-nitropropionic acid lesioning via induction of nf-e2 related factor 2 mediated transcription

vitro+vivo,

AD,

*NRF2↑, *ARE↑, *neuroP↑, *BDNF↑, *GSH↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

ARE↑, 1, GSH↑, 1, NRF2↑, 1,

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,

Functional Outcomes ⓘ

neuroP↑, 1,
Total Targets: 5

Scientific Paper Hit Count for: ARE, antioxidant responsive element (ARE)

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells