polyethylene glycol / BAX Cancer Research Results
PEG, polyethylene glycol: Click to Expand ⟱
| Features: |
PEG polyethylene glycol often used for nano particle stabilization.
-Prevents aggregation, reduces opsonization
-Increases half-life and stability
-improves tumor targeting (EPR effect)
repeated PEG exposure can trigger anti-PEG antibodies (found in ~20–40% of humans), which may Reduce therapeutic effectiveness
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BAX, Apoptosis regulator BAX: Click to Expand ⟱
| Source: |
| Type: Proapototic protein |
BAX is a member of the Bcl-2 gene family.
Pro-apoptotic protein that forms heterodimers with anti-apoptotic BCL2 proteins; involved in various cellular activities and regulated by p53; mediates the release of cytochrome c from mitochondria.
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
Melanoma, |
U266 |
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tumCV↓, selectivity↑, ROS↑, MMP↓, Apoptosis↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
ROS↑, 1,
Mitochondria & Bioenergetics ⓘ
MMP↓, 1,
Cell Death ⓘ
Apoptosis↑, 1, BAX↑, 1, Bcl-2↓, 1, Casp3↑, 1, Casp9↑, 1,
Transcription & Epigenetics ⓘ
tumCV↓, 1,
Drug Metabolism & Resistance ⓘ
selectivity↑, 1,
Total Targets: 9
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: BAX, Apoptosis regulator BAX
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:372 Target#:26 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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