Oleocanthal / Apoptosis Cancer Research Results

OLEC, Oleocanthal: Click to Expand ⟱

Features:

Oleocanthal is a phenolic compound found ONLY in extra-virgin olive oil (EVOO).

It has strong anti-inflammatory activity (similar to ibuprofen-like COX inhibition).
In multiple cell and animal studies, it:
-selectively induces lysosomal membrane permeabilization in cancer cells, leading to rapid cell death
-inhibits tumor proliferation and metastasis pathways
-reduces HER2 signaling
-slows colorectal, breast, and prostate cancer progression in models

It has indirect CSC targeting

Not available as a supplement
-it is unstable outside the oil.
-some companies sell high-oleocanthal EVOO

Apoptosis, Apoptosis: Click to Expand ⟱

Source:

Type: type of cell death

Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.

Scientific Papers found: Click to Expand⟱

4648-

OLEC,

The Effect of Dietary Intervention With High-Oleocanthal and Oleacein Olive Oil in Patients With Early-Stage Chronic Lymphocytic Leukemia: A Pilot Randomized Trial

Trial,

CLL,

40 ml/day of high OC/OL-EVOO (416 mg/Kg OC and 284 mg/kg OL)

Apoptosis↑, *QoL↑,

4649-

OLEC,

Anticancer molecular mechanisms of oleocanthal

Apoptosis↑, HGF/c-Met↝, STAT3↝,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis↑, 2, HGF/c-Met↝, 1,

Proliferation, Differentiation & Cell State ⓘ

STAT3↝, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Functional Outcomes ⓘ

QoL↑, 1,
Total Targets: 1

Scientific Paper Hit Count for: Apoptosis, Apoptosis

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells