xanthohumol / Apoptosis Cancer Research Results

Xan, xanthohumol: Click to Expand ⟱

Features:

Xanthohumol is a prenylated chalcone flavonoid derived from hops (Humulus lupulus).

Commonly described actions include:
-Inflammation suppression: attenuation of NF-κB / STAT3 signaling
-Cell-cycle and survival effects: pro-apoptotic signaling, mitochondrial stress
-Angiogenesis inhibition: reduced VEGF signaling in models
-Metabolic stress modulation: interference with lipid and glucose handling
-Redox effects: antioxidant at low/physiologic exposure; pro-oxidant stress at higher concentrations

Importantly, dose, timing, and cellular context determine which mechanism dominates.

Xanthohumol is best described as chemopreventive or chemo-sensitizing, not chemoprotective:

Apoptosis, Apoptosis: Click to Expand ⟱

Source:

Type: type of cell death

Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.

Scientific Papers found: Click to Expand⟱

5015-

Xan,

PEITC,

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo

in-vitro,

HCC,

HepG2

NRF2↓, ROS↑, NF-kB↓, COX2↓, Apoptosis↑, NRF2↑, SOD↑, NQO1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

NQO1↑, 1, NRF2↓, 1, NRF2↑, 1, ROS↑, 1, SOD↑, 1,

Cell Death ⓘ

Apoptosis↑, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 1, NF-kB↓, 1,
Total Targets: 8

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Apoptosis, Apoptosis

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells