Omeprazole / P-gp Cancer Research Results

Ome, Omeprazole: Click to Expand ⟱

Features:

Omeprazole is a proton pump inhibitor (PPI) used mainly for GERD, ulcers, and other acid-related disorders. Pharmacologically, it is a benzimidazole prodrug that becomes active in an acidic environment and irreversibly inhibits the gastric H+/K+-ATPase proton pump, reducing stomach acid secretion.
-Possible long-term cancer risk associations, especially for gastric cancer in observational studies -Possible Direct anticancer or chemosensitizing effects in preclinical models.

P-gp, permeability-glycoprotein: Click to Expand ⟱

Source:

Type:

P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), is a membrane protein that plays a crucial role in the transport of various substances across cellular membranes. It is part of the ATP-binding cassette (ABC) transporter family.
P-glycoprotein is often overexpressed in a variety of cancers, including breast cancer, lung cancer, leukemia, and ovarian cancer.

- The overexpression of P-glycoprotein (P-gp), is widely considered as an important reason for the MDR (multidrug resistance).

Scientific Papers found: Click to Expand⟱

5442-

AG,

Ome,

Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats

in-vivo,

Nor,

orally administered omeprazole (2 mg/kg), with or without AS-IV (100 mg/kg/day for 7 days) pretreatment

male Sprague-Dawley rats

*other?, *P-gp↑, *CYP3A4↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Core Metabolism/Glycolysis ⓘ

CYP3A4↑, 1,

Transcription & Epigenetics ⓘ

other?, 1,

Barriers & Transport ⓘ

P-gp↑, 1,
Total Targets: 3

Scientific Paper Hit Count for: P-gp, permeability-glycoprotein

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells