Butein / antiOx Cancer Research Results

BUT, Butein: Click to Expand ⟱
Features:

Butein - 2',3,4,4'-Tetrahydroxychalcone

Type: Chalcone / polyphenolic flavonoid-related compound

Function: Butein is a chalcone/polyphenol found in plants such as Rhus verniciflua, Dalbergia odorifera, and Butea monosperma. Butein is a naturally occurring chalcone with antioxidant, anti-inflammatory, and antiproliferative activity. It can modulate signaling pathways including STAT3, NF-κB, PI3K/AKT, MAPK, and redox-sensitive pathways and can influence apoptosis, cell-cycle progression, migration, invasion, and angiogenesis.

Cancer: Preclinical studies show broad anticancer activity, including inhibition of proliferation, migration, invasion, epithelial-mesenchymal transition, angiogenesis, and pro-survival signaling, together with induction of apoptosis and cell-cycle arrest in multiple cancer models.
antiOx, anti-oxidant activities: Click to Expand ⟱
Source:
Type:
Various antioxidants such as Nrf2, SODs, catalase, GPxs, PRDXs, and GSTs are altered in different cancers and have been linked to prognosis. Their overexpression can correlate with aggressive tumor behavior and resistance to treatment in many contexts.
Scientific Papers found: Click to Expand⟱
7782- ISL,  BUT,  SCP,    Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1/ADAM10 signaling pathway
- in-vitro, AD, SH-SY5Y
*Inflam↓, *AntiBio↑, *antiOx↑, *Apoptosis↓, *ROS↓, *SIRT1↑, *FOXO3↑, *ADAM10↑, *Bcl-2↝, *Catalase↑, *SOD2↑, *neuroP↑, *GSR↑, *GPx↑, *GSH↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSR↑, 1,   ROS↓, 1,   SOD2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bcl-2↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO3↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10↑, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 15

Scientific Paper Hit Count for: antiOx, anti-oxidant activities
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:458  Target#:1103  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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