Butein / ADAM10 Cancer Research Results

BUT, Butein: Click to Expand ⟱
Features:

Butein - 2',3,4,4'-Tetrahydroxychalcone

Type: Chalcone / polyphenolic flavonoid-related compound

Function: Butein is a chalcone/polyphenol found in plants such as Rhus verniciflua, Dalbergia odorifera, and Butea monosperma. Butein is a naturally occurring chalcone with antioxidant, anti-inflammatory, and antiproliferative activity. It can modulate signaling pathways including STAT3, NF-κB, PI3K/AKT, MAPK, and redox-sensitive pathways and can influence apoptosis, cell-cycle progression, migration, invasion, and angiogenesis.

Cancer: Preclinical studies show broad anticancer activity, including inhibition of proliferation, migration, invasion, epithelial-mesenchymal transition, angiogenesis, and pro-survival signaling, together with induction of apoptosis and cell-cycle arrest in multiple cancer models.
ADAM10, A Disintegrin And Metalloproteinase Domain-Containing Protein 10: Click to Expand ⟱
Source:
Type:
ADAM10 (A Disintegrin And Metalloproteinase Domain-Containing Protein 10) plays a critical protective role in Alzheimer’s disease (AD) due to its function as an α-secretase, an enzyme involved in the non-amyloidogenic processing of the amyloid precursor protein (APP).
-By preventing Aβ accumulation, ADAM10 indirectly reduces amyloid plaques.br> -Downregulation of ADAM10 is observed in AD brains.
-ADAM10 levels are especially diminished in individuals with an APOE4 genotype
Scientific Papers found: Click to Expand⟱
7782- ISL,  BUT,  SCP,    Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1/ADAM10 signaling pathway
- in-vitro, AD, SH-SY5Y
*Inflam↓, *AntiBio↑, *antiOx↑, *Apoptosis↓, *ROS↓, *SIRT1↑, *FOXO3↑, *ADAM10↑, *Bcl-2↝, *Catalase↑, *SOD2↑, *neuroP↑, *GSR↑, *GPx↑, *GSH↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSR↑, 1,   ROS↓, 1,   SOD2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bcl-2↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO3↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10↑, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 15

Scientific Paper Hit Count for: ADAM10, A Disintegrin And Metalloproteinase Domain-Containing Protein 10
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:458  Target#:1368  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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