Morin / compIII Cancer Research Results

MOR, Morin: Click to Expand ⟱
Features:

Morin - 2',3,4',5,7-Pentahydroxyflavone

Recommended Abbreviation: MOR

Type: Flavonol / polyphenolic flavonoid

Sources: Morin occurs naturally in several plants and foods, including members of Morus, Maclura, Artocarpus, and Psidium species.

Function: Morin is a polyphenolic flavonol with antioxidant, anti-inflammatory, metabolic, neuroprotective, and antiproliferative activities. It modulates oxidative stress, mitochondrial function, inflammatory signaling, apoptosis, cell-cycle regulation, and signaling pathways including NF-κB, STAT3, PI3K/AKT, MAPK, and GSK-3β.

Cancer: Preclinical studies show broad anticancer activity. Morin can inhibit proliferation, migration, invasion, epithelial-mesenchymal transition, inflammatory signaling, and angiogenic pathways while promoting apoptosis and cell-cycle arrest. Reported molecular pathways include STAT3, NF-κB, PI3K/AKT, MAPK, Hippo, MMPs, and ROS-related signaling. Human anticancer efficacy has not been established.

Alzheimer's Disease: Preclinical evidence suggests neuroprotective activity. Morin can reduce amyloid-β-induced oxidative stress, mitochondrial dysfunction, calcium dysregulation, and neuronal injury and may inhibit GSK-3β-related signaling relevant to tau hyperphosphorylation and amyloid pathology. Evidence remains experimental, with no established clinical efficacy for Alzheimer's disease.
compIII, Mitochondrial complex III: Click to Expand ⟱
Source:
Type:
Complex III is part of the mitochondrial respiratory chain. It plays a key role in oxidative phosphorylation by transferring electrons from ubiquinol (coenzyme Q) to cytochrome c.
• The complex is made up of multiple subunits. In humans, some of the key proteins include:
-UQCRC1 (ubiquinol-cytochrome c reductase core protein I)
-UQCRC2 (core protein II)
-UQCRFS1 (the Rieske iron-sulfur protein)
-UQCRB (cytochrome b)

Complex III is a significant source of reactive oxygen species (ROS) when electron transport is inefficient. Increased ROS can promote DNA damage and genomic instability, factors known to drive cancer progression.
Expression levels of Complex III subunits, particularly UQCRFS1 and UQCRC1, have been evaluated as biomarkers. High expression may suggest a more aggressive tumor phenotype, thus linking mitochondrial respiratory chain activity with clinical outcomes.
Scientific Papers found: Click to Expand⟱
7817- ISQ,  MOR,    Morin and isoquercitrin protect against ischemic neuronal injury by modulating signaling pathways and stimulating mitochondrial biogenesis
- in-vitro, AD, NA
*neuroP?, *compI↑, *compIII↑, *compV↑, *p‑ERK↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

compV↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

compI↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compIII↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↑, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP?, 1,  
Total Targets: 5

Scientific Paper Hit Count for: compIII, Mitochondrial complex III
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:460  Target#:1070  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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