Vanillic Acid / Learn Cancer Research Results

VA, Vanillic Acid: Click to Expand ⟱
Features:

Vanillic Acid - 4-Hydroxy-3-Methoxybenzoic Acid

Type: Phenolic acid / hydroxybenzoic acid derivative

Sources: Vanillic acid occurs naturally in numerous plants and foods and is also produced through metabolism of other phenolic compounds including vanillin and ferulic-acid-related compounds.

Function: Vanillic acid is a naturally occurring phenolic acid with antioxidant, anti-inflammatory, metabolic, and antiproliferative activities. It can influence oxidative stress, mitochondrial function, apoptosis, cell-cycle regulation, inflammatory signaling, and pathways including NF-κB, PI3K/AKT/mTOR, JAK/STAT, and MAPK signaling.

Cancer: Preclinical studies demonstrate antiproliferative, pro-apoptotic, anti-invasive, anti-migratory, and anti-angiogenic effects. Reported mechanisms include inhibition of NF-κB, PI3K/AKT/mTOR and JAK/STAT signaling, reduction of VEGF, MMP-2 and MMP-9, cell-cycle arrest, and modulation of mitochondrial apoptosis and oxidative stress. Clinical anticancer efficacy has not been established.

Alzheimer's Disease: Preliminary and indirect evidence suggests potential neuroprotective relevance through antioxidant, anti-inflammatory, mitochondrial, and anti-apoptotic mechanisms. Vanillic acid occurs among bioactive constituents of medicinal plants investigated in Alzheimer's disease models, but direct evidence for vanillic acid as an Alzheimer's treatment remains limited.
Learn, Learning: Click to Expand ⟱
Source:
Type:

Learning ability
Scientific Papers found: Click to Expand⟱
7834- VA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, *memory↑, *Learn↑, *Aβ↓, *BACE/β-secretase↓, *NeuroI↓, *RAGE↓, *antiOx↑, *NRF2↑, *HO-1↑, *GSK‐3β↓, *ROS↓, *AChE↓, *Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Learn↑, 1,   NeuroI↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,  

Migration(tgid=13) ⓘ

RAGE↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,   neuroP↑, 1,  
Total Targets: 15

Scientific Paper Hit Count for: Learn, Learning
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:465  Target#:1656  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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