Acer okamotoanum / adiP Cancer Research Results

AO, Acer okamotoanum: Click to Expand ⟱
Features:

Acer okamotoanum - Acer okamotoanum Extract

Alternative Names: Acer okamotoanum, Ulleungdo maple

Type: Botanical extract / flavonoid-rich plant product

Source: Acer okamotoanum is a maple species native to Korea, particularly Ulleung Island. Experimental studies have used leaf extracts and solvent fractions, including flavonoid-rich ethyl acetate fractions.

Active Constituents: Reported constituents include isoquercitrin, quercitrin, afzelin, and other phenolic and flavonoid compounds.

Function: Acer okamotoanum extracts exhibit antioxidant, anti-inflammatory, cytoprotective, and neuroprotective activities. Experimental studies show reductions in reactive oxygen species, lipid peroxidation, inflammatory signaling, and apoptotic damage, together with preservation of neuronal viability and cellular stress resistance.

Alzheimer's Disease: Preclinical evidence suggests potential neuroprotective and cognition-preserving effects. Acer okamotoanum extract has improved learning and memory and reduced oxidative stress in experimental models involving amyloid-β and metabolic stress. Constituents including isoquercitrin, quercitrin, and afzelin may contribute to these effects through antioxidant, anti-inflammatory, and amyloid-related mechanisms. Clinical efficacy for Alzheimer's disease has not been established.
adiP, adiponectin: Click to Expand ⟱
Source:
Type:
Adiponectin is an adipokine with anti-inflammatory and insulin-sensitizing properties, and its effects on tumor biology are thought to be mediated through influences on cell proliferation, apoptosis, and metabolic regulation.

Adiponectin is a key metabolic hormone whose levels have been associated with cancer risk and prognosis across multiple tumor types. Generally, lower adiponectin levels tend to correlate with more aggressive tumor phenotypes and poorer outcomes, while higher levels may offer a degree of protection.
Scientific Papers found: Click to Expand⟱
7839- AO,  ISQ,    The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model
- in-vivo, AD, NA - in-vivo, Obesity, NA
*Dose↝, *Obesity↓, *Leptin↓, *adiP↑, *hepatoP↑, *PSEN1/PS1↓, *PSEN2/PS-2↓, *BACE/β-secretase↓, *eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Leptin↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,   Obesity↓, 1,  
Total Targets: 9

Scientific Paper Hit Count for: adiP, adiponectin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:466  Target#:1191  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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